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Workshops

The most notable and exciting work from all abstracts submitted to the conference will be honored with an oral presentation in these sessions. Presenters are expected to explain their work and answer questions from the audience.

Workshops Track A

WS.A1.01  Myeloid lineage specifications
Sunday, September 2, 2018; 16:30-17:45; Room: G106-107

Tissue resident mast cells are of dual hematopoietic origin
R. Gentek, Marseille, France

Determining dendritic cell ontogeny across organs by cellular barcoding
T. Tak, A. Magniez, L. Perié, Paris, France

Bone marrow-resident dendritic cells play an important role in anti-fungal immunity by boosting granulopoiesis upon recognition of yeast particles.
M. Goedhart, E. Slot, M. F. Pascutti, S. Geerman, T. Rademakers, B. Nota, C. Voermans, M. A. Nolte, Amsterdam, Netherlands

Common monocyte progenitors are novel antimycobacterial effector cells
P. Henneke, A. Lösslein, Freiburg, Germany

Identification of the unique functional phenotype of iMATE-defining monocytes that drive hepatic T cell proliferation
K. Pawelka, P. Knolle, M. Heikenwälder, Munich, Germany

C/EBPα is crucial in early dendritic cell development
A. Muralikrishnan, A. Rosenberger, E. Schwarzenberger, H. Strobl, A. Zebisch, H. Sill, A. Wölfler, Graz, Austria

WS.A2.01  T cells in aging
Monday, September 3, 2018; 16:30-17:45; Room: E102

Characherisation of IL 10 producing CD4+ T cells in aged mice
I. M. Ogunsulire, M. Almanan, D. Hildeman, C. Hölscher, Sülfeld, Germany    

Peripheral Antibody titers are affected by highly differentiated, senescent, and exhausted T cells, and pro-inflammatory changes in the human Bone Marrow.
E. C. Naismith, L. Pangrazzi, C. Miggitsch, M. Grasse, B. Weinberger, K. Trieb, B. Grubeck-Loebenstein, Innsbruck, Austria    

Strong homeostatic TCR signals induce formation of self-tolerant virtual memory CD8 T cells
A. Moudra, A. Drobek, D. Mueller, M. Huranova, V. Horkova, M. Pribikova, R. Ivanek, S. Oberle, D. Zehn, K. D. McCoy, P. Draber, O. Stepanek, Prague, Czech Republic    

Extreme memory inflation of HLACw0702 restricted CMV specific CD8+ T cells that dominate the CD8+ T cell repertoire during healthy ageing
L. Hosie, A. Pachnio, J. Zuo, H. Pearce, S. Riddell, P. Moss, Birmingham, United Kingdom    

Age-Related Decline in Primary CD8+ T Cell Responses is Associated with the Development of Senescence in a Subset of Antigenically Naive CD8+ T Cells
N. L. La Gruta, K. M. Quinn, A. Fox, K. L. Harland, B. E. Russ, J. Li, T. H. Nguyen, L. Loh, M. Olshansky, H. Naeem, K. Tsyganov, F. Wiede, R. Webster, C. Blyth, X. Y. Sng, T. Tiganis, D. Powell, P. C. Doherty, S. J. Turner, K. Kedzierska, Clayton, Australia    

Influence of aging on calcium signals and cytotoxicity in murine CD8+ T cells
A. Angenendt, R. Steiner, A. Knörck, G. Schwär, E. Krause, A. Lis, Homburg, Germany

 

WS.A2.02 Immune development and neonatal responses
Tuesday, September 4, 2018; 10:15-11:30;
Room: E102

Dynamic transcriptome-proteome correlation networks contribute to human myeloid differentiation and neutrophil development
A. J. Hoogendijk, M. van den Biggelaar, F. Pourfarzad, C. Aarts, A. Tool, I. Hiemstra, F. van Alphen, C. van der Zwaan, T. K. van den Berg, L. Grassi, M. Frontini, W. H. Ouwehand, A. B. Meijer, T. W. Kuijpers, Amsterdam, Netherlands    

CircRNA expression is a highly regulated process during hematopoiesis and lymphocyte differentiation
B. P. Nicolet, S. Engels, F. Aglialoro, E. van den Akker, M. von der Lindern, M. C. Wolkers, Amsterdam, Netherlands    

IL-2-vs. IL-15-dependent intrathymic development of regulatory T lymphocytes
C. APERT, N. McJannett, P. Romagnoli, J. van Meerwijk, TOULOUSE, France    

Recent thymic emigrants in neonates and adults share an antimicrobial molecular signature
M. L. Pekalski, A. Rubio Garcia, A. Paterou, R. C. Ferreira, D. B. Rainbow, A. J. Cutler, J. L. Jones, J. A. Todd, L. S. Wicker, Oxford, United Kingdom    

Characterising the maturation of T cell polarisation in preterm and term infants and in the neonatal chronic lung disease bronchopulmonary dysplasia
J. C. Lao, M. A. Pang, A. Malhotra, K. Tan, F. Beker, K. Konig, C. Collins, C. Theda, O. Kamlin, P. J. Berger, A. Veldman, C. A. Nold-Petry, M. F. Nold, Clayton, Australia    

CD4+ T cells from human neonates and infants respond extensive against antigens of Candida albicans and Aspergillus fumigatus
K. Vogel, M. Pierau, A. Arra, K. Lampe, D. Schlueter, C. Arens, M. C. Brunner-Weinzierl, Magdeburg, Germany    


WS.A2.03  Immune cell aging and differentiation
Tuesday, September 4, 2018; 14:45-16:00; Room: E102

Identification of age-related immune signatures by mass cytometry
J. Braun, S. Schlickeiser, A. Andrzejewska, F. Papatzika, B. Kruse, S. Geissler, A. Arampatzis, A. Thiel, Berlin, Germany

Aging affects the frequency, functions and antibody repertoire of human B-1 cells
A. M. Hernández-Vázquez, N. Rodríguez-Zhurbenko, T. Quach, T. J. Jopkings, T. L. Rothstein, Havana, Cuba    

T cell immunity does not age in a long-lived rodent species
M. Izraelson, T. Nakonechnaya, A. Davydov, M. Dronina, D. Miskevich, I. Mamedov, L. Barbashova, M. Shugay, D. Bolotin, D. Staroverov, E. Kondratyuk, S. Lukyanov, I. Shams, O. Britanova, D. Chudakov,, Moscow, Russian Federation  

Antigen-specific immunity is inhibited in the skin of older people by p38 MAPK-driven inflammatory monocytes.
E. S. Chambers, M. Vukmanovic-Stejic, H. Trahair, A. Appios, V. Birault, M. Noursadeghi, N. Mabbott, M. Rustin, A. Akbar, London, United Kingdom  

Screen of epigenetic inhibitors reveals two novel T helper 17 (Th17) cell regulators: BRPF1 and BRPF2.
L. Chen, N. Zaarour, T. Sekine, M. Sundstrom, M. Feldmann, A. Cribbs, F. McCann, P. Bowness, Oxford, United Kingdom    

Differentiation of human Langerhans cells from monocytes and their specific function in inducing IL-22-specific T helper cells
Y. Otsuka, E. Watanabe, E. Shinya, H. Saeki, T. B. Geijtenbeek, H. Takahashi, Tokyo, Japan

 

WS.A2.04  Evolution of immune responses in health and disease
Wednesday, September 5, 2018; 13:45-15:00; Room: G106-107

Hematopoietic progenitors from old humans are metabolically active but present evidence of cellular senescence and pyroptosis 
T. Fali, V. Fabre Mersseman, T. Yamamoto, J. Boddaert, D. Sauce, V. Appay, Paris, France,

IMMUNOBIOGRAM a new immunological tool to personalize immunosuppressive therapy in kidney transplant recipients
M. Di Scala, J. Portolés, C. Jiménez, D. Janeiro, E. González, B. Sánchez Sobrino, M. López Oliva, J. Richter, A. Ortega, J. Pascual, I. Portero, Madrid, Spain

Particular neutrophils mediate environment-driven onset of airway allergy through NETs release 
C. Radermecker, C. Sabatel, S. Johnston, M. Toussaint, F. Bureau, T. Maricha, Sart-Tilman, Belgium

Alpha-Gal bound to lipids, but not to proteins, is able to cross the intestinal epithelium and might thus cause delayed allergic symptoms in meat allergic patients
P. Román-Carrasco, B. Lieder, V. Somoza, M. Ponce, Z. Szépfalusi, D. Martín, W. Hemmer, I. Swoboda, Vienna, Austria

Cytofast: A workflow for mass cytometry data to establish high-dimensional immune signatures 
G. Beyrend, K. Stam, T. Höllt, R. Arens, Leiden, The Netherlands

A novel algorithm for analysis оf the evolution of B-cell receptors repertoires using high-throughput sequencing data
A. S. Obraztsova, M. Shugay, D. M. Chudakov, Moscow, Russian Federation

WS.A3.01 Immunobiomarkers in autoimmunity and beyond
Monday, September 3, 2018; 10:15-11:30; Room: G102-103

Dissecting IL-12p70 response variability in health and disease
C. Posseme, B. Charbit, A. Llibre, A. Bisiaux, B. Piasecka, E. Nemes, T. Scriba, L. Quintana-Murci, S. Pol, M. L. Albert, D. Duffy, Paris, France    

New protein array technology identifies rituximab treated non responder rheumatoid arthritis patients are generating a new autoantibody repertoire
Z. Konthur, M. Wiemkes, T. Häupl, G. Burmester, K. Skriner, Berlin, Germany    

Imbalance of naïve and memory T cells in peripheral lymphocyte subpopulations at onset of type 1 diabetes
A. Teniente-Serra, E. Pizarro, M. Julian, M. Fernández, E. Martínez-Cáceres, Badalona, Spain    

Glycolytic T cell metabolism drives faster disease progressionin progressive multiple sclerosis patients
S. DE BIASI, E. Bianchini, M. Nasi, L. Gibellini, S. Pecorini, D. Lo Tartaro, A. Simone, D. Ferraro, F. Vitetta, P. Sola, A. Cossarizza, M. Pinti, MODENA, Italy    

Measurement of serum infliximab levels and detection of free and bound anti-infliximab antibodies in patients with rheumatoid arthritis.
C. Hermanrud, M. Ryner, R. Pullerits, K. Hambardzumyan, N. Vivar Pomiano, P. Marits, I. Gjertsson, S. Saevarsdottir, A. Fogdell-Hahn, Stockholm, Sweden    

Imaging flow cytometry enhances the detection of small particles and rare events enabling emerging applications in immunology and oncology
P. Rhein, A. Goergens, B. Giebel, S. Groenefeld-Krentz, C. Eckert, Darmstadt, Germany


WS.A3.02  Biomarkers of adaptive immunity
Tuesday, September 4, 2018; 10:15-11:30; Room: Forum

Rapid identification and isolation of functional antigen-specific CD8+ T cells by staining of activated integrins
S. Dimitrov, C. Gouttefangeas, L. Besedovsky, A. T. Jensen, A. Chandrand, E. Rusch, R. Businger, M. Schindler, T. Lange, J. Born, H. Rammensee, Tübingen, Germany    

Epigenetic signatures of human T helper cell subsets
A. Ntalli, S. Kumar, L. Maggi, F. Annunziato, C. Zinser, M. Beckstette, L. Graca, S. Floess, J. Huehn, Braunschweig, Germany    

The cold shock protein YB-1 (Y-box binding protein 1) promotes survival of CD4+ T-lymphocytes
S. Meltendorf, S. Gieseler-Halbach, J. Handschuh, M. Pierau, A. Arra, P. R. Mertens, U. Thomas, M. C. Brunner-Weinzierl, Magdeburg, Germany    

Tissue resident memory T cells as a progressive multifocal leukoencephalopathy quick biomarker
A. Tejeda Velarde, E. Rodríguez Martín, L. Costa-Frossard, Y. Aladro, S. Sainz de la Maza, S. Medina, N. Villarrubia, E. Monreal, E. Roldán, J. Álvarez-Cermeño, L. Villar, Madrid, Spain    

T3SS components as the biomarkers of humoral immune response elicited by live bacterial vaccine in humans
V. A. Feodorova, A. M. Lyapina, M. A. Khizhnyakova, S. S. Zaitsev, L. V. Sayapina, M. V. Telepnev, O. V. Ulianova, E. P. Lyapina, S. S. Ulyanov, V. L. Motin, Saratov, Russian Federation    

Skin-homing human CD8+ T cells preferentially express GPI-anchored peptidase inhibitor 16 (PI16), an inhibitor of cathepsin K
N. Lupsa, B. Érsek, A. Bencsik, A. Horváth, E. Lajkó, Á. Oszvald, Z. Wiener, P. Reményi, G. Mikala, T. Masszi, E. Buzás, Z. Pós, Budapest, Hungary    


WS.A3.03  Immune markers in malignancies
Tuesday, September 4, 2018; 14:45-16:00; Room: G102-103

NSCLC patients not responding to nivolumab show lowered frequency of co-stimulatory receptor-deficient CD8 T cells
A. Kunert, E. A. Basak, D. P. Hurkmans, Y. Klaver, M. van Brakel, A. Oostvogels, C. H. Lamers, S. Bins, S. L. Koolen, A. A. van der Veldt, S. Sleijfer, R. H. Mathijssen, J. G. Aerts, R. Debets, Rotterdam, Netherlands    

Circulating CD4 senescent T cells stratify clinical responses to PD-L1/PD-1 immune checkpoint inhibitors in NSCLC
M. Zuazo, H. Arasanz, M. Gato, G. Fernández, R. Vera, G. Kochan, D. Escors,, Pamplona, Spain    

CD103 tumor Infiltrating lymphocytes as a prognostic factor in colon cancer patients
S. M. Talhouni, J. Ramage, Nottingham, United Kingdom    

Filgrastim enhances T-cell clearance by anti-thymocyte globulin exposure after unrelated cord blood transplantation
C. de Koning, J. A. Gabelich, J. Langenhorst, R. Admiraal, J. Kuball, J. J. Boelens, S. Nierkens, Utrecht, Netherlands    

Next-generation antigen receptor sequencing of paired diagnosis and relapse samples of B-cell acute lymphoblastic leukemia: an algorithm for Minimal Residual Disease target selection
P. Theunissen, M. de Bie, D. van Zessen, V. de Haas, A. P. Stubbs, V. H. J. van der Velden, Rotterdam, Netherlands

Plasma-derived exosomes in head and neck squamous cell carcinoma patients as potential biomarkers of response to immune therapies
M. Theodoraki, T. Hoffmann, R. Ferris, T. Whiteside, Ulm, Germany

WS.A4.01  Germinal center reactions
Monday, September 3, 2018; 08:30-09:45; Room: E104-107

Follicular dendritic cells originate from subepithelial mesenchymal cells in Peyer’s patches
A. Prados, V. Koliaraki, G. Kollias,, Vari, Greece    

Novel branched proximity hybridization assay to quantify nanoscale protein-protein interaction
S. Zheng, M. Mitterer, M. Reth, M. Cavallari, J. Yang, Freiburg, Germany    

Reconstitution of T-cell synaptic ectosomes unravels vesicular CD40L density as a critical determinant in the feed forward activation of antigen presenting cells
P. F. Céspedes-Donoso, D. G. Saliba, S. Valvo, S. Balint, K. Korobchevskaya, E. Compeer, M. Tognolli, E. O´Neill, M. L. Dustin, Oxford, United Kingdom    

In follicular regulatory T cells NFATc1 is essential for homing to germinal centers
A. Koenig, M. Vaeth, G. Müller, S. Klein-Hessling, M. Klein, D. Stauss, L. Dietz, T. Bopp, M. Lipp, I. Berberich, F. Berberich-Siebelt, 97080 Würzburg, Germany    

Ectopic lung resident germinal centres are formed during chronic house dust mite driven allergic airway disease in a T follicular helper cell dependent manner
F. I. Uwadiae, R. Siroya, A. Gerasimov, C. Spilsbury, C. J. Pyle, S. A. Walker, C. M. Lloyd, J. A. Harker, London, United Kingdom   

Antigen stimulation of lymphoid cells supports alternative pathway of T Follicular helper cell differentiation by polarizing CD45RA- CD4 T cells into Tfh cells
R. Jeger-Madiot, M. Pereira, C. Richetta, V. Quiniou, P. Buffet, D. Klatzmann, A. Moris, S. Graff-Dubois, Paris, France    

 


WS.A4.02  Regulation of B cell development and differentiation
Tuesday, September 4, 2018; 14:45-16:00; Room: G104-105

B cell positive selection is developmentally regulated during ontogeny by the heterochronic protein Lin28b
S. Vanhee, S. Datta, T. Kristiansen, H. Åkerstrand, S. Lang, S. Vergani, A. Doyle, K. Olsson, S. Soneji, E. Jaensson Gyllenbäck, J. Yuan, Lund, Sweden    

The bHLH transcription factor TCFL5 and its soform CHA differently modulate c-MYC-dependent B cell proliferation
I. Sánchez-Gómez, J. Galán-Martinez, M. Maza, K. Stamatakis, N. Gironès, M. Fresno, Madrid, Spain    

PI3Kδ hyper-activation in B cells promote increased susceptibility to S. pneumoniae airway infection through an antibody independent mechanism.
A. Stark, A. Chandra, R. Alam, K. Okkenhaug,, Cambridge, United Kingdom    

Expansion of activated CXCR5+ICOS+Tfh cells and plasmablasts induced by seasonal influenza vaccine is impaired in anti-IL-6R treated rheumatoid arthritis patients
A. Agua-Doce, V. Romao, J. Polido-Pereira, R. Barros, I. P. Lopes, M. I. Seixas, M. J. Saavedra, E. Sacadura-Leite, H. Rebelo-de-Andrade, J. E. Fonseca, L. Graca, Lisboa, Portugal

Functions of ZBTB24 in human and murine B cells
C. Zhu, Y. Zhao, J. Liang, X. Gao, J. Wang, Suzhou, China    

Stem cell based gene therapy for Recombinase deficient-SCID
F. J. T. Staal, K. Pike-Overzet, Leiden, Netherlands

WS.A5.01  Innate effectors in the onset of immune responses
Sunday, September 2, 2018; 16:30-17:45; Room: G104-105

Inflammation-induced cancer and cancer-induced inflammation in colon: a role for S1P lyase
A. Schwiebs, M. Herrero, E. Wiercinska, M. Anlauf, F. Ottenlinger, K. Schmidt, D. Thomas, E. Elwakeel, A. Weigert, H. Bonig, K. Scholich, G. Geisslinger, J. M. Pfeilschifter, H. H. Radeke, Frankfurt, Germany    

CD28 co-stimulation during antigenic recall responses of CD4+Th1 cells triggers IFNg secretion in vivo
S. Haack, D. Langenhorst, F. Lühder, T. Hünig, N. Beyersdorf, Würzburg, Germany   

Blood transcriptomic analysis shows how recall innate responses are modulated by the use of an adjuvant at priming
E. Pettini, F. Santoro, D. Kazmin, A. Ciabattini, F. Fiorino, G. Gilfillan, I. Evenroed, P. Andersen, G. Pozzi, D. Medaglini, Siena, Italy, Italy    

DNGR-1 dampens neutrophil recruitment to damaged tissues, fostering disease tolerance upon infection
C. Del Fresno Sánchez, P. Saz-Leal, M. Enamorado, S. Wculek, S. Martínez-Cano, N. Blanco-Menéndez, O. Schulz, M. Gallizioli, F. Miró, E. Cano, A. Planas, C. Reis e Sousa, D. Sancho, Madrid, Spain    

Toll-like receptor signalling induces a temporal switch from inflammatory towards a more resolving lipid profile in monocyte-derived macrophages
J. von Hegedus, M. Heijink, T. Huizinga, M. Kloppenburg, M. Giera, R. Toes, A. Ioan-Facsinay, Amsterdam, Netherlands    

OX40 is required for both Th17 and Th1 effector T cell programmes
D. Gajdasik, C. Willis, R. Fiancette, M. Botto, T. Vyse, G. Frankel, D. Ruano-Gallego, D. Withers, Birmingham, United Kingdom

 


WS.A5.02  Early T cell functions in immune responses
Monday, September 3, 2018; 14:45-16:00; Room: G102-103

Mature CD10+and immature CD10-neutrophils present in G-CSF-treated donors display opposite effects on T cells
O. Marini, S. Costa, D. Bevilacqua, F. Calzetti, N. Tamassia, C. Spina, D. De Sabata, E. Tinazzi, C. Lunardi, M. T. Scupoli, C. Cavallini, E. Zoratti, I. Tinazzi, A. Marchetta, A. Vassanelli, M. Cantini, G. Gandini, A. Ruzzenente, A. Guglielmi, F. Missale, Verona, Italy    

Tight translational control of glycolysis and fatty acid metabolism regulates the transition of CD4+ T cells from quiescence to metabolic remodelling
S. Ricciardi, N. Manfrini, R. Alfieri, P. Calamita, M. Crosti, R. Muller, M. Pagani, S. Abrignani, S. Biffo,, Milan, Italy    

Regulatory and conventional T cell transcription factors are reciprocally controlled during Salmonella infection
S. Clay, A. Bravo Blas, D. Wall, M. MacLeod, S. Milling, Glasgow, United Kingdom   

CD28 costimulation and not TCR controls the effector functions of activated CD4 T cells
B. Soskic, D. A. Glinos, D. M. Sansom, G. Trynka, Cambridge, United Kingdom    

The genome organizer Satb1 is required for the development of TH17 cells through regulation of IL-2 expression
M. Köhne, D. Sommer, J. Schulte-Schrepping, L. Schmidleithner, K. Klee, J. Wißfeld, L. Holsten, K. Händler, M. Geyer, T. Kuhlmann, J. Alferink, C. Wickenhauser, J. L. Schultze, M. Beyer, Bonn, Germany    

Unique metabolic requirements for T helper 2 polarization by dendritic cells
L. Pelgrom, A. Sergushichev, A. J. van der Ham, B. M. Winkel, M. Yazdanbakhsh, M. N. Artyomov, B. Everts, Leiden, Netherlands    

 


WS.A5.03  DC and tissue-derived cellular responses
Monday, September 3, 2018; 16:30-17:45; G102-103

Engulfment and active shuttling of mast cell granules boosts dendritic cell functions
J. Kotrba, J. Dudeck, J. Froebel, A. Dudeck, Magdeburg, Germany    

Cross-dressing of mast cells with MHC II from dendritic cells during skin Inflammation
J. Dudeck, A. Medyukhina, J. Froebel, J. Kotrba, M. Figge, A. Dudeck, Magdeburg, Germany    

CD86+ antigen-presenting B cells are increased in solid cancers and induce tumor antigen-specific T cell responses
K. Wennhold, M. Thelen, A. Lechner, H. Schlößer, M. von Bergwelt-Baildon,, Cologne, Germany    

Beta2-integrins restrict dendritic cell migratory phenotype through MRTFA/SRF signaling and a Syk-dependent epigenetic mechanism
C. Guenther, M. Fusciello, M. Ilander, M. Sokolova, T. Savinko, L. Uotila, S. Yao, M. Moser, S. W. Morris, V. Cerullo, S. Tojkander, M. Vartiainen, S. C. Fagerholm, Helsinki, Finland    

Expanded T-cell clones are present in the synovium before the clinical onset of rheumatoid arthritis
G. Balzaretti, P. L. Klarenbeek, M. E. Doorenspleet, M. J. de Hair, B. C. van Schaik, R. E. Esveldt, M. G. van de Sande, D. M. Gerlag, A. H. van Kampen, F. Baas, P. Tak, N. de Vries, Amsterdam, Netherlands    

Systems metabolic profiling reveals synergistic control of naive T cell priming by autophagy and mTOR
N. Franceco, L. Papagno, A. Caputo, V. Appay, Padova, Italy

WS.A6.01 Lessons learned from genetic defects
Monday, September 3, 2018; 08:30-09:45; Room: E102

CLIP upregulation on B cells associates with multiple sclerosis onset and is governed by autoimmunity risk allele CLEC16A
L. Rijvers, M. Melief, M. Stéphant, J. van Langelaar, R. M. van der Vuurst de Vries, A. F. Wierenga-Wolf, M. van Ham, R. Q. Hintzen, M. M. van Luijn, Rotterdam, Netherlands    

CD55deficientpatient PBMCs respond differentially to TLR, Inflammasome and patient exosome stimulation before and after Eculizumab therapy.
G. G. Kaya, M. Yildirim, I. Evcili, N. Bozbeyoglu, I. C. Ayanoglu, A. Ozen, S. Sari, B. Dalgic, M. Gursel, I. Gursel, Ankara, Turkey   

A Th17 cell specific migration defect provides protection from EAE in DOCK8 deficient mice
A. S. Wilson, H. Law, C. B. Knobbe-Thomsen, C. J. Kearney, J. Oliaro, C. Binsfeld, G. Burgio, L. Starrs, D. Brenner, K. L. Randall, A. Brüstle, Canberra, Australia   

Consequences of an IL2RA locus duplication in a very early onset inflammatory bowel disease patient
M. E. Joosse, F. Charbit-Henrion, R. C. Raatgeep, D. J. Lindenbergh-Kortleve, L. M. Costes, L. M. Costes, S. Nugteren, S. Veenbergen, V. Malan, J. K. Nowak, M. Mearin, J. C. Escher, N. Cerf-Bensussan, J. N. Samsom, Rotterdam, Netherlands  

Tetratricopeptide repeat domain 7 a regulates haematopoietic stem cell functions by controlling the stress-induced response.
C. Leveau, M. El-Daher, N. Cagnard, A. Fischer, G. de Saint Basile, F. Sepulveda, Paris, France    

Coincidence of a novel NFKB1 mutation with a Crohn-associated NOD2 rare variant in a patient may explain her profound common variable immunodeficiency (CVID) phenotype with unusually severe gastrointestinal manifestations.
M. Martinez-Gallo, R. Dieli-Crimi, C. Franco-Jarava, M. Antolin, L. Blasco, P. Paramonov, A. Álvarez Fernández, X. Molero, J. Velázquez, A. Martín-Nalda, R. Pujol-Borrell, R. Colobran, Barcelona, Spain

Workshops Track B

WS.B1.01 Immune checkpoints in anti-tumor therapy
Monday, September 3, 2018; 14:45-16:00; Room: E104-107

Impact of tumor heterogeneity on response to immune checkpoint inhibition
S. Sánchez Alonso, G. Setti Jeréz, M. Arroyo Correa, T. Hernandez Paredero, A. Alfranca González, Madrid, Spain    

Rational therapeutic modulation of the tumour microenvironment sensitizes cancers to immune checkpoint blockade
R. M. Zemek, E. De Jong, W. L. Chin, V. Fear, C. Forbes, T. Casey, A. R. Forrest, D. O'Muiri, M. Small, A. Zaitouny, M. J. Millward, A. K. Nowak, T. Lassman, R. A. Lake, A. Bosco, W. J. Lesterhuis,, Perth, Australia    

Molecular recalibration of PD-1+ antigen-specific T cells as immunotherapy for Hepatocellular carcinoma
I. Otano, D. Escors, A. Schurich, H. Singh, F. Robertson, B. Davidson, G. Fusai, F. A. Vargas, Z. Tan, J. Aw, N. Hansi, P. Kennedy, S. Xue, H. Stauss, A. Bertoletti, A. Pavesi, M. K. Maini, London, United Kingdom    

CD47-SIRPa checkpoint blockade involves kindlin3-dependent enhancement of CD11b/CD18-integrin affinity and cytotoxic synapse formation
P. Bouti, H. Matlung, M. van Houdt, P. Verkuijlen, K. Franke, T. W. Kuijpers, T. K. van den Berg,, Amsterdam, Netherlands    

HVEM as a new checkpoint blockade for cancer immunotherapy
P. KC, S. Brunel, N. Aubert, D. Olive, G. Marodon, Paris, France    

Gastro-intestinal Stromal Tumors show enhanced numbers of checkpoint-negative CD8 T-cells
Y. Klaver, M. Rijnders, A. Oostvogels, R. Wijers, M. Smid, D. Grunhagen, C. Verhoef, S. Sleijfer, C. Lamers, R. Debets, Rotterdam, Netherlands

 

WS.B1.02  Novel targets in anti-cancer immune therapy

Tuesday, September 4, 2018; 10:15-11:30; Room: E104-107

BAFF-R as a novel therapeutic target for Acute Lymphoblastic Leukemia.
R. Parameswaran, Y. Vicioso, Cleveland, United States    

Investigation of novel immunotherapeutic targets for colorectal cancer
D. Shinko, H. McGuire, T. Ashhurst, S. Clarke, S. Byrne, K. Charles, Sydney, Australia    

IL-1R8 is a novel checkpoint regulating anti-tumor and anti-viral activity of NK cells
M. Molgora, E. Bonavita, A. Ponzetta, F. Riva, M. Barbagallo, S. Jaillon, B. Popovic, G. Bernardini, E. Magrini, F. Gianni, S. Zelenay, S. Jonjic, A. Santoni, C. Garlanda, A. Mantovani, Pieve Emanuele, Italy    

Glycan modified vesicles as a targeted and personalized vaccination strategy for the induction of anti-tumor immunity
S. K. Horrevorts, D. A. Stolk, S. J. van Vliet, T. D. de Gruijl, A. A. van de Loosdrecht, Y. van Kooyk, Amsterdam, Netherlands    

Heme as a modulator of the therapeutic efficacy of an anti-cancer antibody
A. Tavares-Kanyavuz, A. Marey-Jarossay, S. Lacroix-Desmazes, J. Dimitrov, 75006 Paris, France    

Evaluation of a New Anti-Galectin 9 Immunotherapy Strategy in Pancreatic Cancers
A. Quilbe, R. Mustapha, S. Renaud, B. Duchêne, C. De Schutter, G. Herlin, O. Moralès, I. Van Seuningen, N. Jonckheere, N. Delhem, 59021 Lille Cedex, France  

 

WS.B1.03 Genetically engineered TCR for immunotherapy

Tuesday, September 4, 2018; 14:45-16:00; Room: E104-107

Development and characterization of novel anti-GD2 target modules for retargeting of Universal CAR T cells toward GD2 expressing tumors
N. Mitwasi, A. Feldmann, R. Bergmann, N. Berndt, C. Rössig, M. Bachmann,, Dresden, Germany    

Functional comparison of CARs targeting CD20 with a TCR directed against a CD20 derived peptide
T. L. A. Wachsmann, L. Jahn, E. van Diest, J. Leusen, J. Kuball, J. Falkenburg, M. Heemskerk, Leiden, Netherlands    

Impaired Early Downstream Signaling Blunts Antigen Sensitivity of CAR-T-cells
V. Gudipati, J. Rydzek, I. Perez, S. Königsberger, H. Stockinger, M. Hudecek, J. Huppa, Vienna, Austria    

Antitumor activity by TEGs: alpha/beta T cells engineered to express a defined gamma/delta TCR in a 3D bone marrow niche model of multiple myeloma
T. Straetemans, M. Braham, T. Aarts-Riemens, J. Alblas, M. Minnema, Z. Sebestyen, J. Kuball, Utrecht, Netherlands    

Engineering antigen-specific Natural Killer cells against the melanoma-associated antigen tyrosinase via TCR gene transfer
A. Parlar, C. Pamukcu, E. C. Sayitoglu, A. Georgoudaki, D. Ozkazanc, M. Aras, M. Chrobok, P. Zahedimaram, L. Ikromzoda, E. Alici, B. Erman, A. D. Duru, T. Sutlu, Istanbul, Turkey    

TCR replacement in the endogenous locus via non-viral CRISPR-Cas9-mediated knock-in
K. Schober, T. Müller, D. H. Busch,, München, Germany


WS.B1.04   Antigen specificity in anti-tumor immunity
Tuesday, September 4, 2018; 16:30-17:45; Room: G106-107

Towards the next generation CAR T cells with TEGs: in vivo efficacy - toxicity profile in xenografts of primary human AML disease and healthy bone marrow
I. Johanna, T. Straetemans, S. Heijhuurs, T. Aarts-Riemens, H. Norell, L. Bongiovanni, A. de Bruin, Z. Sebestyen, J. Kuball, Utrecht, The Netherlands    

Harnessing Pre-Existing Antiviral Immunity to Treat Solid Tumors
N. Cuburu, R. Kim, S. M. Pontejo, C. D. Thompson, D. R. Lowy, J. T. Schiller, Bethesda, United States    

Ephemeral immune control of cytomegalovirus infection by T-cells recognizing a single viral epitope
F. Mbui, L. Borkner, Z. Chaudhry, L. Cicin-Sain, Braunschweig, Germany    

Autologous neo-antigen-specific T cell responses in low mutation burden colorectal cancers
J. van den Bulk, D. Ruano, M. Visser, M. IJsselsteijn, R. van der Breggen, K. Peeters, S. van der Burg, E. Verdegaal, N. de Miranda, Leiden, Netherlands  

A minority of tumor associated antigen specific T-cells restricted to self-HLA alleles is of sufficient avidity to recognize overexpressed endogenously processed antigen
M. Roex, L. Hageman, E. van Egmond, S. Veld, C. Hoogstraten, L. Germeroth, F. Falkenburg, I. Jedema, Leiden, Netherlands    

Cross-reactive CD8+ T cell receptor clonotypes elicited by influenza epitope variants are drawn from a narrow repertoire distinct from non-cross-reactive receptors
P. G. Thomas, P. Dash, P. Bradley, A. Williams, S. Duan, Memphis, United States


WS.B1.05  Anti-tumor immunology
Wednesday, September 5, 2018; 08:30-09:45; Room: G104-105

Dissecting the immune heterogeneity of neuroblastoma microenviroment in murine models to develop novel therapeutic strategies for high-risk neuroblastoma patients
V. Lucarini, O. Melaiu, M. Vinci, M. Compagnone, G. Ziccheddu, L. Cifaldi, V. Pistoia, D. Fruci, Rome, Italy    

Deficiency of host CD96 and PD-1 or TIGIT enhances tumor immunity without significantly compromising immune homeostasis
H. Harjunpaa, S. J. Blake, E. Ahern, S. Allen, J. Liu, J. Yan, V. Lutzky, K. Takeda, A. Roman Aguilera, C. Guillerey, D. Mittal, X. Y. Li, W. C. Dougall, M. J. Smyth, M. W. Teng,, Brisbane, Australia    

Stromal Protein βig-h3 Reprograms Tumor Microenvironment in Pancreatic Cancer
D. Goehrig, J. Nigri, R. Samain, Z. Wu, C. Paola, G. Gabiane, X. Zhang, Y. Zhao, I. Kim, M. Chanal, R. Curto, V. Hervieu, C. de la Fouchardière, F. Novelli, P. Milani, R. Tomasini, C. Bousquet, P. Bertolino, A. Hennino, Lyon, France    

Retargeting T cells against leukemia by lipid-specific TCR transfer
M. Consonni, C. Garavaglia, C. de Lalla, A. Bigi, A. Mancino, M. Casucci, A. Bondanza, M. Lepore, L. Mori, G. De Libero, F. Ciceri, P. Dellabona, G. Casorati, Milano, Italy    

Chorioallantoic membrane model to study glycan dependent tumor growth and differentiation
N. M. Sahasrabudhe, L. Cornelissen, K. Castricum, J. van der Horst, V. L. Thijssen, S. J. van Vliet, Amsterdam, Netherlands    

An NK cell-driven inflammatory switch regulated by cyclooxygenase-2 activity restricts tumor growth and predicts cancer patient outcome
E. Bonavita, V. S. Pelly, C. Bromley, E. Flanagan, S. Sahoo, H. Leong, S. Zelenay, Manchester, United Kingdom

 


WS.B1.06 Anti-tumor strategies
Wednesday, September 5, 2018; 12:00-13:15; Room: G102-103

Revisiting the role of type 1 conventional dendritic cells (cDC1) in cancer immunosurveillance and in responses to immunotherapies against cancer
R. Mattiuz, J. Cancel, L. Pouyet, F. Romagné, N. Bendriss-Vermare, C. Caux, J. Valladeau-Guilemond, M. Dalod, K. Crozat, Marseille, France    

Generation of Memory Stem T cells specific for tumor antigens and resistant to inhibitory signals by genome editing
B. C. Cianciotti, A. Potenza, Z. Magnani, V. Vavassori, P. Genovese, L. Naldini, E. Ruggiero, C. Bonini, Milan, Italy    

A CD3xCD19 bispecific DART®molecule induces T-cell mediated killing of CLL cells in vitro
A. W. J. Martens, S. R. Janssen, L. Izhak, A. P. Kater, G. J. van der Windt, Amsterdam, Netherlands    

MDM2-targeting as a new Natural Killer cell-based immunotherapy of neuroblastoma
I. Veneziani, E. Ferretti, D. Fruci, L. Moretta, V. Pistoia, F. Locatelli, L. Cifaldi, Rome, Italy    

Mutated NPM1 as target for immunotherapy of acute myeloid leukemia
D. I. van der Lee, R. M. Reijmers, M. W. Honders, R. S. Hagedoorn, R. M. de Jong, M. G. Kester, D. M. van der Steen, A. H. de Ru, H. M. Bijen, C. Kweekel, I. Jedema, H. Veelken, M. H. Heemskerk, P. A. van Veelen, F. J. Falkenburg, M. Griffioen, Leiden, Netherlands    

Enhanced immunogenicity of mitochondrial localised mutated proteins in cancer cells
G. Prota, U. Gileadi, M. Rei, A. Lechuga Vieco, J. Chen, J. Rehwinkel, A. Ahmed, J. Enríquez, V. Cerundolo, Oxford, United Kingdom

WS.B2.01  Environmental regulation of anti-tumor responses
Sunday, September 2, 2018; 16:30-17:45; Room: G102-103

High glycolytic tumors evade immune destruction by acidosis-dependent induction of ICER in tumor-associated macrophages
T. Bohn, S. Rapp, M. Klein, S. Pektor, K. Renner, M. Kreutz, V. Popp, K. Gerlach, B. Weigmann, C. Lueckel, M. Huber, C. Becker, E. von Stebut-Borschitz, H. Schild, E. Schmitt, T. Bopp, Mainz, Germany    

Carcinoma-associated pancreatic stellate cells induce CD4+ and CD8+ T-cell exhaustion
L. Gorchs, C. Fernández Moro, Q. Meng, E. Rangelova, H. Kaipe,, Stockholm, Sweden    

The tumour microenvironment supports the self-renewal of tumour-promoting macrophages in colon adenoma.
I. Soncin, J. Sheng, Q. Chen, K. Karjalainen, C. Ruedl, Singapore, Singapore    

Fatty acid metabolism complements glycolysis in the selective regulatory T cell expansion during tumor growth
I. Pacella, C. Procaccini, C. Focaccetti, S. Miacci, E. Timperi, D. Faicchia, M. Severa, F. Rizzo, E. M. Coccia, F. Bonacina, N. Mitro, G. D. Norata, G. Rossetti, V. Ranzani, M. Pagani, E. Giorda, Y. Wei, G. Matarese, V. Barnaba, S. Piconese,, Rome, Italy    

IL-18 is a key driver of immunosuppression and a therapeutic target in multiple myeloma
S. Kassem, K. Nakamura, H. Avet-Loiseau, M. J. Smyth, L. Martinet, TOULOUSE, France    

Chronic lymphocytic leukemia impairs metabolic fitness in CD8 T cells
A. van Bruggen, A. Martens, J. A. Fraietta, M. Levin, P. J. Siska, S. Endstra, J. C. Rathmell, J. J. Melenhorst, A. P. Kater, G. J. van der Windt, Amsterdam, Netherlands


WS.B2.02  Tumor immune surveillance and evasion
Monday, September 3, 2018; 14:45-16:00; Room: G104-105

Tumor immune evasion arises through loss of TNF sensitivity
J. Oliaro, C. Kearney, S. Vervoort, R. Johnstone, Melbourne, Australia    

IL-33/ST2 signaling promotes the survival and proliferation of AML1/ETO leukemic stem cells
P. Näf, R. Radpour, C. Riether, A. F. Ochsenbein,, Bern, Switzerland    

Characterizationof CC-chemokine Receptor 6 (CCR6) and CC-chemokine Ligand 20 (CCL20) mediated immunosurveillance in the initiation and progression of malignant melanoma
D. Martin-Garcia, A. H. Enk, A. S. Lonsdorf, Heidelberg, Germany    

Unraveling the mechanism behind aberrant CD37 expression in human B cell lymphoma
S. Elfrink, C. de Winde, M. van den Brand, E. Jansen, F. Doubrava-Simmer, S. van Deventer, C. Hess, W. Stevens, D. van Spronsen, H. van Krieken, C. Figdor, B. Scheijen, A. van Spriel, Nijmegen, Netherlands    

A generic, cost-efficient high performance capillary liquid chromatography-high resolution mass spectrometry method for quality control of peptide pools
G. Bosc-Bierne, V. Armuzza, M. G. Weller, O. J. Kreuzer, Berlin, Germany    

G-MDSC derived exosomes promote the progression of colon cancer
S. Wang, Y. Wang, J. Ma, H. Xu, Zhenjiang, China    


WS.B2.03  Innate anti-tumor immunity
Tuesday, September 4, 2018; 08:30-09:45; Room: G104-105

The macrophage tetraspan MS4A4A interacts with Dectin-1 and is required for macrophage-NK cell cross-talk and resistance to metastasis
I. Mattiola, F. Tomay, M. De Pizzol, B. Savino, T. Gulic, R. Silva-Gomes, R. Carriero, D. Morone, I. N. Shalova, Y. Lee, S. K. Biswas, G. Mantovani, M. Sironi, B. Bottazzi, A. Mantovani, M. Locati,, Berlin, Germany    

Heparanase is required for dendritic cell-natural killer cell crosstalk and subsequent natural killer cell activation
A. Mayfosh, N. Baschuk, Melbourne, Australia    

CD137 (4-1BB) costimulation counteracts TGF-β1 inhibition of antibody-dependent NK cell responses against HER2+ transformed cells
M. Cabo, R. Lozano-Rodríguez, M. Ataya, M. Costa-Garcia, S. Santana, M. C. Ochoa, P. Berraondo, I. Melero, M. López-Botet, A. Muntasell, Barcelona, Spain    

B7H6, a ligand for NKp30, is regulated by BRD4 in acute myeloid leukemia cells
A. Baragaño Raneros, P. Díaz Bulnes, R. M. Rodriguez, B. Suárez Álvarez, C. López Larrea, Oviedo, Spain    

Identification and functional properties of mature and immature neutrophils in homeostasis, inflammation and cancer
J. B. G. Mackey, R. Jackstadt, T. Jamieson, A. McFarlane, X. L. Raffo, D. Patel, J. Secklehner, J. Vuononvirta, R. Snelgrove, J. Morton, J. Norman, O. J. Sansom, L. M. Carlin,, London, United Kingdom    

Epithelial damage and tissue γδ T cells promote a unique tumour-protective IgE response
G. Crawford, R. Castro Seoane, S. Ward, M. Hayes, M. Haniffa, D. Dunn-Walters, J. Strid, London, United Kingdom

WS.B3.01 Molecular regulation of T cell responses
Monday, September 3, 2018; 10:15-11:30; Room: G106-107

Resident CD4+ T cells in secondary lymphoid organs
A. C. Kaminski, O. Pabst, M. Ugur, Aachen, Germany    

Production of extracellular adenosine by CD73+ dendritic cells is crucial for induction of T cell hyporesponsiveness
C. Silva-Vilches, K. Mahnke, Heidelberg, Germany    

EGFR-HIF1α signaling positively regulates the development of Th9 cells
S. Roy, Z. Rizvi, A. Awasthi, Faridabad, India    

Post-transcriptional regulation of cytokine production in T cells by RNA binding proteins
B. Popovic, F. Şalerno, S. Engels, F. van Alphen, A. Guislain, B. P. Nicolet, M. C. Wolkers, Amsterdam, Netherlands    

Lysosome-related organelle tethering controls directionally distinct cytokine transport in T cells
B. Qu, Y. Zhou, R. Zhao, E. C. Schwarz, R. Akbar, V. Pattu, V. Helms, H. Rieger, Homburg, Germany    

Targeting E3 ubiquitin ligase receptor cereblon to stimulate Myc-driven metabolismin CD8+ T cells
R. Hesterberg, A. A. Akuffo, M. S. Beatty, W. E. Goodheart, M. Fernandez, J. L. Cleveland, P. K. Epling-Burnette, Tampa, United States

 


WS.B3.02  T cell mediated immune regulation in tumors
Wednesday, September 5, 2018; 13:45-15:00; Room: G102-103

HDAC7 controls CD8+ T cell dependent anti-tumor immunity
C. Yerinde, J. Keye, F. Schmidt, B. Siegmund, R. Glauben, C. Weidinger,, Berlin, Germany    

Deciphering the molecular pathways underlying oncogenic IL-7R signaling in T-cell acute lymphoblastic leukemia
A. Murcia Ceballos, P. Fuentes Villarejo, S. González García, M. García Peydró, J. Alcain, E. García Martínez, A. A. Ferrando, M. Toribio, Madrid, Spain 

Epithelial signals promote local effector Foxp3+ regulatory T cell accumulation in the gut
A. Bremser, H. Meinicke, A. Izcue, Aachen, Germany  

Intravital signaling visualization reveals that transient productive interactions between T regulatory cells and classical DC support cancer immune tolerance
F. Marangoni, E. Carrizosa, V. Mani, M. Thelen, J. Prüssmann, T. R. Mempel, Charlestown, United States    

The CD58-CD2 axis controls killing of leukemic B cells by cytotoxic T lymphocytes
V. Zurli, T. Montecchi, G. Wimmer, O. Acuto, C. Baldari, A. Kabanova, Siena, Italy  

Functional anti-TIGIT antibodies modulate T cell responses in vivo
K. O. Dixon, M. Schorer, J. Nevin, Y. Etminan, Z. Amoozgar, T. Kondo, S. Kurtulus, N. Kassam, R. A. Sobel, D. Fukumura, R. K. Jain, A. C. Anderson, V. K. Kuchroo, N. Joller, Zurich, Switzerland

 

WS.B3.03  T cell responses in health and disease
Wednesday, September 5, 2018; 13:45-15:00; Room: G104-105

Loss of NIK in thymic epithelial cells leads to fatal autoimmunity through aberrant Treg development
C. Haftmann, F. Mair, E. Terskikh, M. Spalinger, B. P. Leung, A. Waisman, B. Becher, Zürich, Switzerland

A Timer for analyzing temporally dynamic changes in transcription during T cell differentiation in vivo
D. Bending, P. Prieto Martín, A. Paduraru, C. Ducker, E. Marzaganov, M. Laviron, T. Crompton, M. Ono, London, United Kingdom

A temporally dynamic Foxp3 autoregulatory transcriptional circuit controls the effector Treg programme 
D. Bending, A. Paduraru, C. Ducker, P. Prieto Martin, T. Crompton, M. Ono, Birmingham, United Kingdom

N4BP1 and TNIP1 control MHC-1 display on neuroblastoma tumors 
L. Spel, J. Nieuwenhuis, R. Haarsma, E. Stickel, O. Bleijerveld, M. Altelaar, j. Boelens, T. Brummelkamp, S. Nierkens, M. Boes, Utrecht, The Netherlands 

T cell-induced tumor vulnerability discovery in anIFNg-independent genomic landscape 
D. Peeper, Amsterdam, The Netherlands

NKG2A blockade potentiates CD8+ T-cell immunity induced by cancer vaccines 
T. van Hall, N. van Montfoort, L. Borst, M. J. Korrer, Y. Kim, S. Santegoets, M. Welters, P. Andre, S. Piersma, S. H. van der Burg, Leiden, The Netherlands

WS.B4.01 Molecular control of T cell activation and exhaustion
Tuesday, September 4, 2018; 16:30-17:45; Room: E104-107

PTPN22-deficient CD8 T cells resist TGFb suppression and mediate improved anti-tumour responses
R. J. Brownlie, C. Garcia, M. Ravasz, D. Zehn, R. Zamoyska, R. J. Salmond, Leeds, United Kingdom    

Heterochromatin silencing of stemness during CD8+ T cell fate commitment
l. Pace, C. Goudot, E. Zueva, P. Gueguen, N. Burgdorf, J. Waterfall, J. Quivy, G. Almouzni, S. Amigorena,, Turin, Italy    

TLR9 signaling mediates functional responses induced by direct ligation of ODN 2216 in CD4+CD25- effector T cells
R. K. Sharma, J. Sharma, P. Jain, A. Gupta, N. Sachdeva, Chandigarh, India    

The T cell genome in 3D: how higher order chromatin structures regulate virus-specific T cell differentiation
B. E. Russ, M. Olshansky, Z. He, J. Paulsen, S. Tomei, J. Li, P. Collas, C. Murre, S. J. Turner, Clayton, Australia    

Deep phenotyping of colorectal cancers by high-dimensional mass cytometry reveals tumor-specific immune landscapes
N. L. de Vries, V. van Unen, T. R. Abdelaal, M. E. van Herk, R. van der Breggen, A. Farina Sarasqueta, K. C. Peeters, T. Höllt, B. P. Lelieveldt, F. Koning, N. F. de Miranda, Leiden, Netherlands    

ATTACK, a novel bispecific T cell-recruiting antibody with trivalent EGFR binding and monovalent CD3 binding for cancer immunotherapy
S. Harwood, S. Lykkemark, A. Ana Alvarez-Cienfuegos, N. Natalia Nuñez-Prado, M. Compte, S. Hernandez-Perez, N. Merino, J. Bonet, R. Navarro, P. M. van Bergen en Henegouwen, K. Mikkelsen, K. Mølgaard, F. Jabs, L. Sanz, F. J. Blanco, P. Roda-Navarro, L. Alvarez-Vallina, Aarhus, Denmark    

 


WS.B4.02  Targeting checkpoints
Wednesday, September 5, 2018; 08:30-09:45; Room: Forum

Improving anti-CD137 immunotherapy against multiple myeloma through PD1 blockade
A. C. Pichler, Toulouse, France    

PD-1 Signals are Critical for Maintenance of Functional CD8 T Cell Memory
S. Sarkar, Y. Yuzefpolskiy, F. Baumann, K. Ernst-Bernhard, M. Prlic, P. Nghiem, S. Riddell, M. Sedensky, P. Morgan, M. C. Jensen, V. Kalia, Seattle, United States    

Combination therapy with anti-PD-L1 antibody and depletion of regulatory T cells during acute viral infections results in improved virus control but lethal immunopathology
M. Drabczik-Pluta, P. David, E. Pastille, T. Knuschke, T. Werner, N. Honke, A. M. Westendorf, K. S. Lang, U. Dittmer, G. Zelinskyy, Essen, Germany    

Plasticity of Tc17 cells is regulated by CTLA-4 via STAT1/3
A. Arra, H. Lingel, B. Kuropka, T. Fischer, C. Freund, M. Pierau, M. Brunner-Weinzierl, Magdeburg, Germany    

De novo DNA methylation programming restrains T cell rejuvenation during immune checkpoint blockade therapy
H. Ghoneim, A. Moustaki, H. Abdelsamed, Y. Fan, P. Thomas, E. Stewart, S. Federico, B. A. Youngblood, Memphis, United States    

Mitochondrial morphological and functional reprogramming following CD137 (4-1BB) co-stimulation
I. Etxeberria, S. Labiano, S. Garasa, E. Santamaría, A. Rouzaut, M. Enamorado, A. Azpilikueta, S. Inoges, E. Bolaños, M. Aznar, A. Sánchez-Paulete, D. Sancho, I. Melero, A. Teijeira,, Pamplona, Spain

Workshops Track C

WS.C1.01  Regulation in tissue specific autoimmunity 1
Monday, September 3, 2018; 08:30-09:45; Room: G102-103

Human skin-resident and functionally competent memory T cells survive myeloablation preceding allogeneic hematopoietic stem cell transplantation
J. Strobl, N. Bayer, M. Mayrdorfer, B. Reininger, L. Hammerl, S. Saluzzo, P. Kalhs, W. Rabitsch, G. Hopfinger, G. Stary, Vienna, Austria    

Phenotypic, molecular and functional characterisation of pro-inflammatory IL-17+ CD8+ T (Tc17) cells in psoriatic arthritis
K. J. Steel, U. Srenathan, L. E. Durham, S. Wu, M. L. Ridley, E. Chan, B. W. Kirkham, L. S. Taams, London, United Kingdom    

Lymphoid neogenesis in kidneys during lupus: involvement of CXCR3-expressing T cells
R. Veber, C. Le Coz, S. Lecomte, F. Monneaux, K. A. Fenton, H. Dumortier, Strasbourg, France    

Intracapillary immune complexes recruit and activate slan-expressing CD16+ monocytes in human lupus nephritis
F. Olaru, T. Döbel, A. Lonsdorf, A. Enk, H. Gröne, K. Schäkel, Heidelberg, Germany    

Tbet provides advantage to Tregs for homing into type 1 inflammation sites in vivo
B. Akkaya, M. Akkaya, A. H. Holstein, J. Al Souz, M. P. Maz, E. M. Shevach, Bethesda, United States    

Nox2 deficiency in CD4+CD25+FoxP3+ T cells limits angiotensin II-induced hypertension and cardiovascular remodelling
S. Cellone Trevelin, A. Emerson, H. Mongue-Din, P. D. Becker, C. Ortiz, L. A. Smyth, G. Sawyer, A. Ivetic, Q. Peng, R. Elgueta, R. I. Lechler, A. M. Shah, G. Lombardi, London, United Kingdom

 

WS.C1.02   Immune regulation at mucosal sites
Tuesday, September 4, 2018; 10:15-11:30; Room: G104-105

Intestinal Secretory Leukocyte Protease Inhibitor expression is increased in pediatric inflammatory bowel disease patients and is unfavorable during murine colitis
S. Nugteren, C. L. Menckeberg, Y. Simons-Oosterhuis, D. J. Lindenbergh-Kortleve, L. A. van Berkel, H. C. Raatgeep, L. M. Costes, L. de Ridder, J. C. Escher, J. N. Samsom, Rotterdam, Netherlands    

ATF3 is crucial for intestinal mucosal immunity during homeostasis and stress
D. Glal, Taipei, Taiwan    

The transcription factor MAF regulates homeostasis in colonic T cells
C. Imbratta, M. Leblond, D. Velin, D. E. Speiser, G. Verdeil, Epalinges, Switzerland    

Proinflammatory, high avidity CD4+ T cells with a memory-like phenotype in the human fetal intestine
N. Li, V. van Unen, T. Abdelaal, K. Ladell, J. E. McLaren, D. A. Price, S. M. Chuva de Sousa Lopes, B. P. Lelieveldt, F. Koning, Leiden, Netherlands    

The transcription factor NFATc3 promotes intestinal inflammation by suppression of regulatory T cells
K. Gerlach, V. Popp, M. Neurath, B. Weigmann, Erlangen, Germany    

The molecular composition of IgA anti-carbamylated and anti-citrullinated protein antibodies in Rheumatoid Arthritis, point to a mucosal origin
M. A. M. van Delft, M. K. Verheul, N. Levarht, L. Hafkenscheid, T. Kissel, A. Bondt, T. W. Huizinga, R. E. Toes, L. A. Trouw, Leiden, Netherlands

 

WS.C1.03  Cytokine and transcription factor mediated immune regulation
Wednesday, September 5, 2018; 08:30-09:45; Room: E104-107

Anti-TNF treatment leads to delayed activation, maturation and proliferation of CD4+ T cells but does not confer a global suppressive phenotype
G. A. M. Povoleri, S. Lalnunhlimi, K. Steel, S. Agrawal, M. Ridley, S. Kordasti, C. Roberts, L. S. Taams, London, United Kingdom    

Vγ6+ γδ17 T cells home to the male reproductive tract and expand at puberty to keep pathogens at bay
H. Brigas, A. Wilharm, I. Sandrock, T. Amado, T. Carvalho, A. Reinhardt, B. Silva-Santos, I. Prinz**, J. Ribot**, Lisboa, Portugal    

IL-27 increases the plasticity of differentiated Th17 cells by inducing IL-12R beta2 expression
A. Awasthi, V. K. Kuchroo, Faridabad, India    

TGF-β bioactivity in Trichuris muris homogenate induces FOXP3+ T regulatory cells and inhibits Th1 and Th2 polarisation when activated
A. E. Ogunkanbi, B. Eldakhakhny, J. L. Pennock, Manchester, United Kingdom    

Hobit identifies precursors of resident memory T cells within the peripheral tissues
L. Parga Vidal, F. Behr, N. Kragten, T. Wesselink, R. Stark, K. van Gisbergen,, Amsterdam, Netherlands    

EOMES-positive CD4+T cells are increased in PTPN22 (1858T) risk allele carriers
K. Chemin, D. Ramsköld, L. Diaz-Gallo, J. Herrath, M. Houtman, K. Tandre, L. Rönnblom, V. Malmström, Stockholm, Sweden

 

WS.C1.04  Regulation in tissue specific autoimmunity 2
Wednesday, September 5, 2018; 08:30-09:45; Room: G106-107

Th17.1 cells preferentially recruit to the central nervous system to mediate early disease activity in multiple sclerosis
J. van Langelaar, R. M. van der Vuurst de Vries, M. Janssen, A. F. Wierenga-Wolf, I. M. Spilt, T. A. Siepman, W. Dankers, G. M. Verjans, H. E. de Vries, E. Lubberts, R. Q. Hintzen, M. M. van Luijn, Rotterdam, Netherlands    

4-1BB overexpression in basal keratinocytes induces the disruption of the eye´s immune privilege
E. Gonnelli, M. Kasper, V. Kupas, D. Bauer, T. A. Luger, A. Heiligenhaus, K. Loser, Münster, Germany    

Targeting CD146 can downregulate new blood vessel formation caused by VEGF-producing T cells in rat experimental autoimmune uveitis
G. Wildner, M. Diedrichs-Möhring, S. Thurau, Munich, Germany    

Persistence of dominant TCRâ clones in regulatory T cells derived from an autoimmune inflammatory environment
G. Mijnheer, J. Leong, A. Boltjes, E. Spierings, A. Petrelli, S. Vastert, S. Albani, A. Pandit, F. van Wijk, Utrecht, Netherlands    

Characterization of constitutively DC-deficient mice in autoimmune responses
C. Hilpert, D. Voehringer, Erlangen, Germany    

Engineering antigen-expressing regulatory T cells to modulate adverse immune responses
D. W. Scott, M. Abdeladhim, A. Zhang, J. H. Yoon, K. Parvathaneni, L. Kropp, Y. C. Kim, E. Mitre, Bethesda, United States

WS.C2.01 Signaling in autoimmunity
Tuesday, September 4, 2018; 08:30-09:45; Room: G102-103  

Induction of gliadin-specific immune inhibition following treatment with Tolerogenic Immune Modifying Nanoparticles (TIMP) containing-gliadin
J. R. Podojil, T. L. Freitag, R. Pearson, D. Getts, L. D. Shea, S. D. Miller, Chicago, United States    

Inhibition of arginase-1 expression by the transcription factor Fra-1 in macrophages exacerbates rheumatoid arthritis inflammation
N. Hannemann, S. Cao, A. Schnelzer, J. Jordan, M. Eberhardt, U. Schleicher, S. Uebe, A. Ekici, J. Rech, T. Bäuerle, C. Bogdan, J. Vera, G. Schett, A. Bozec, Erlangen, Germany    

OPAL1, a novel transmembrane adaptor protein regulates CXCR4 signalling.
Š. Borna, A. Drobek, J. Králová, M. Fabišik, T. Brdička, Prague , Czech Republic  

FcγR-TLR cross-talk promotes inflammation by human antigen presenting cells via IRF5-dependent gene transcription and glycolytic reprogramming

W. Hoepel, L. T. Vogelpoel, I. S. Hansen, M. L. Kapsenberg, D. L. Baeten, B. Everts, J. den Dunnen,, Amsterdam, Netherlands    

Transmembrane TNF signaling through TNF-RI induces SpA-like inflammation, whereas signaling through TNF-RII is crucial for new bone formation.
M. van Tok, D. Pots, I. Blijdorp, M. Armaka, G. Kollias, M. van de Sande, D. Baeten, L. van Duivenvoorde, Amsterdam, Netherlands    

Lactate, via SLC5A12, lights up inflammation in CD4+ T cells by inducing a metabolic reprogramming
V. Pucino, M. Certo, D. Cucchi, M. Lewis, K. Goldmann, M. Bombardieri, C. Pitzalis, C. Mauro, London, United Kingdom

 

WS.C2.02  Neuroinflammatory disorders
Tuesday, September 4, 2018; 10:15-11:30; Room: G102-103

Efficient suppression of effector T cells isolated from multiple sclerosis patients by autologous, UniCAR-engrafted Tregs
A. Kegler, S. Koristka, C. Arndt, A. Feldmann, S. Albert, G. Ehninger, M. Bornhäuser, M. Schmitz, K. Akgün, T. Ziemssen, M. Bachmann, Dresden, Germany    

Elucidation of pro-resolving lipid mediators in the cerebrospinal fluid: implications for multiple sclerosis pathogenesis
G. Kooij, V. Chiurchiù, G. Enzmann, P. Norris, M. Khameni, B. Engelhardt, H. E. de Vries, C. Serhan, Amsterdam, Netherlands    

Characterizing human CD20+ T cells and their role in multiple sclerosis
M. von Essen, C. Ammitzbøll, R. Hansen, O. McWilliam, E. Petersen, H. Marquart, F. Sellebjerg, Copenhagen, Denmark    

Malat-1 LncRNA regulates inflammation and T cell differentiation in an animal model of multiple sclerosis
F. Masoumi, S. Ghorbani, F. Talebi, F. Noorbakhsh, Tehran, Iran, Islamic Republic of    

Dimethyl fumarat limits Tc17 cell fate in autoimmunity via ROS accumulation
C. Lückel, H. Raifer, L. Campos Carrascosa, S. Moos, F. Kurschus, F. Marini, M. Klein, T. Bopp, Y. Chao, C. Zielinski, L. Bonetti, M. Grusdat, D. Brenner, B. Tackenberg, M. Huber, Mainz, Germany  

The TH17-associated cytokine interleukin-26 regulates central nervous system barrier function
B. Broux, E. Peelen, E. Gowing, S. Zandee, M. Charabati, M. Lécuyer, L. Hachehouche, L. Bourbonnière, C. Pittet, S. Larouche, J. I. Alvarez, A. Bouthillier, R. Moumdjian, P. Duquette, N. Arbour, A. Prat, Diepenbeek, Belgium    

 

WS.C2.03  Pathophysiology of autoimmune diseases
Wednesday, September 5, 2018; 12:00-13:15; Room: Forum

Cholesterol metabolism drives the function of regulatory B cells
J. Bibby, A. Cope, E. Perucha, London, United Kingdom    

Neutrophil activation and altered coagulation in a rat model for autoimmune hemolytic anemia
L. Del Vasto Nunez, G. van Mierlo, I. Jongerius, B. M. Luken, N. Juffermans, S. Zeerleder,, Amsterdam, Netherlands    

JMJD3/UTX histone H3K27 demethylases regulate metabolic and inflammatory Th17 cell function in ankylosing spondylitis
A. P. Cribbs, M. Philpott, R. K. Prinjha, P. Wordsworth, P. Bowness, M. Feldmann, U. Oppermann, Oxford, United Kingdom    

Immunoglobulin A activated myeloid cells induce pathological osteoclast activation in rheumatoid arthritis patients
M. M. J. van Gool, A. C. Breedveld, R. E. Mebius, M. van Egmond, Amsterdam, Netherlands    

Anti-Ly9 (CD229) antibody treatment reduces marginal zone B cell numbers and salivary gland inflammation in a mouse model of Sjögren’s Syndrome
J. Puñet-Ortiz, M. Sáez Moya, M. Cuenca, A. Lázaro, J. Boix Nebot, P. Engel, Barcelona, Spain    

Dysregulated expression of RasGRP1 in T cells leads to autoimmunity
T. Douma, D. Simeonov, D. Myers, M. Baars, G. Mijnheer, F. van Wijk, A. Marson, J. Roose, Y. Vercoulen, Utrecht, Netherlands

 

WS.C2.04  Therapy of autoimmune disorders
Wednesday, September 5, 2018; 13:45-15:00; Room: E104-107

Functional reprogramming of regulatory T cells in the absence of Foxp3
L. M. Charbonnier, Y. Cui, D. Lopez, J. J. Bleesing, M. I. Garcia-Lloret, K. Chen, A. Ozen, M. O. Li, T. A. Chatila, Boston, United States    

Immune response profiling reveals signaling networks mediating TNF-blocker function and predictors of therapeutic responses in spondyloarthritis patients
S. Menegatti, V. Rouilly, E. Latis, H. Yahia, E. Mascia, C. Leloup, D. Duffy, A. Urrutia, E. Achouri, L. Quintana-Murci, M. Albert, C. Miceli, M. Dougados, E. Bianchi, L. Rogge,, Paris, France    

Targeting NF-κB signalling in B cells: a potential new treatment modality for antibody mediated autoimmune diseases
J. P. van Hamburg, P. Tuijnenburg, B. Helder, L. van Keep, K. Wesenhagen, P. Kucharzewka, M. H. Jansen, A. Al-Soudi, P. L. Klarenbeek, H. Olsson, N. de Vries, T. W. Kuijpers, S. W. Tas, Amsterdam, Netherlands    

Suppression of autoreactive T and B lymphocytes by selective therapy in humanized murine SCID model of systemic lupus erythematosus
S. Bradyanova, N. Mihaylova, P. Chipinski, E. Ivanova-Todorova, D. Kyurkchiev, M. Herbáth, J. Prechl, A. I. Tchorbanov, Sofia, Bulgaria    

Interleukin-6 Receptor inhibition, as first-line b-DMARD, affects B cell subpopulations distribution through epigenetic modifications in Rheumatoid Arthritis patients
C. Di Mario, B. Tolusso, S. Alivernini, A. Fedele, L. Petricca, M. Gigante, G. Ferraccioli, E. Gremese, Rome, Italy    

Co-engaging CD47 and CD19 with a bispecific antibody impairs B cell proliferation induced by B-cell receptor cross-linking
E. Hatterer, L. Barba, N. Noraz, B. Daubeuf, J. Aubry-Lachainaye, B. van der Weid, F. Richard, W. Ferlin, M. Kosco-Vilbois, V. Buatois, L. Shang, Geneva, Switzerland

WS.C3.01  Transplantation - pathogenesis and early diagnosis
Monday, September 3, 2018; 08:30-09:30; Room: G106-107

Improved risk stratification of pretransplant donor-specific antibodies with epitope analyses
E. G. Kamburova, on behalf of the PROCARE consortium, H. G. Otten, Utrecht, Netherlands    

Detection of alloantibodies against NK cell antigens after transplantation
T. Langer Jacobus, R. E. Schmidt, C. S. Falk, E. Jäckel, F. W. Vondran, C. Ferreira de Figueiredo, R. Jacobs, Hannover, Germany    

HLA Class I Haplotype Diversity Is Consistent with Selection for Frequent Existing Haplotypes
Y. Louzoun, I. Alter, M. Maiers, L. Gragert, Ramat Gan, Israel 

High numbers of donor-specific IL-21 producing cells predict rejection after kidney transplantation
N. M. van Besouw, L. Yan, R. de Kuiper, M. Klepper, D. Reijerkerk, D. L. Roelen, F. H. Claas, M. C. Clahsen-van Groningen, D. A. Hesselink, C. C. Baan, Rotterdam, Netherlands    

Immunization against the polysaccharide Poly-N-acetylglucosamine reduces graft-versus-host disease without affecting microbial diversity
J. Hülsdünker, O. S. Thomas, Z. Gao, S. Duquesne, S. Kirschnek, A. Schmitt-Graeff, M. J. Blaser, G. B. Pier, R. Zeiser, Freiburg, Germany    

Motifs of peptides binding in HLA-DP and their relation with T-cell epitope groups relevant in stem cell transplantation
P. Van Balen, M. G. Kester, W. De Klerk, P. Crivello, A. H. De Ru, M. Van de Meent, I. Jedema, M. H. Heemskerk, K. Fleischhauer, J. H. Falkenburg, P. A. Van Veelen, Leiden, Netherlands

 

WS.C3.02  T regulatory cells derived and other cellular therapies in transplantation
Wednesday, September 5, 2018; 12:00-13:15;
Room: G104-105

Development of a novel protocol to produce massive amounts of autologous thymus-derived Treg cells (thyTreg) to be employed as cellular therapy in transplanted children. A new paradigm in the treatment of immunological diseases
E. Bernaldo de Quirós, V. Pérez, M. Clemente, J. Gil-Jaurena, M. Fernández-Santos, S. Suárez, V. Plasencia, A. Acosta, M. Camino, N. Gil, E. Panadero, C. Medrano, M. Pion, R. Correa-Rocha, Madrid, Spain    

Effective Treg therapy of lethal acute graft-versus-host disease
C. Riegel, T. Böld, E. Huber, P. Hoffmann, M. Edinger, Regensburg, Germany    

Re-directing Treg specificity toward allograft transplants to sustainably prevent rejection
R. Alhamawi, C. Dempsey, R. Albugami, S. Lee, N. D. Jones, Birmingham, United Kingdom    

Extracellular adenosine reversibly inhibits the activation of human regulatory T cells and negatively influences the achievement of the operational tolerance in liver transplantation
A. Baroja-Mazo, B. Revilla-Nuin, L. Martínez-Alarcón, J. Herrero, A. El-Tayeb, C. Müller, P. Aparicio, P. Pelegrín, J. Pons, EL PALMAR- MURCIA, Spain    

Targeting recipient antigen presenting cells with sialic acid- modified alloantigen to promote transplantation tolerance
M. Sen, K. Ratnasothy, M. Ambrosini, D. Guiliano, Y. van Kooyk, G. Lombardi, L. A. Smyth, London, United Kingdom    

Third party virus-specific T-cells for treatment of viral reactivations in immune compromised patients and risks of allo-HLA cross-reactivity
W. Huisman, D. A. Leboux, L. Hageman, D. Amsen, F. J. Falkenburg, I. Jedema, Amsterdam, Netherlands

WS.C4.01 Manipulation of tolerogenic pathways
Sunday, September 2, 2018; 16:30-17:45; Room: E102

PD-1 regulates the expression of HELIOS in self-reactive CD8+ and CD4-CD8-T cells
N. Rodriguez Rodriguez, S. A. Apostolidis, E. Montes Servin, O. Arrieta, G. C. Tsokos, F. Rosetti, J. C. Crispin, Mexico City, Mexico    

Immunotherapy with apitopes® blocks the immune response to thyroid stimulating hormone receptor in HLA-DR transgenic mice
E. Schurgers, F. La Greca, D. C. Wraith, K. F. Martin, L. Jansson, Diepenbeek, Belgium    

Pathogenic antibody development and blister formation due to impaired peripheral tolerance
S. Haeberle, X. Wei, K. Bieber, S. Goletz, E. Schmidt, R. Ludwig, A. Enk, E. Hadaschik, Heidelberg, Germany    

APRIL induces a novel subset of IgA+ regulatory B cells that suppress inflammation through the expression of IL-10 and PD-L1
C. M. Fehres, N. O. Van Uden, N. G. Yeremenko, L. Fernandez, G. Franco Salinas, L. M. Van Duivenvoorde, B. Huard, J. Morel, H. Spits, M. Hahne, D. L. Baeten, Amsterdam, Netherlands    

Molecular Mechanisms of T cell Tolerance Induction
S. T. H. Ng, S. Bevington, P. Cockerill, D. C. Wraith, Birmingham, United Kingdom  

Macrophages treated with exosome-delivered miRNA-150 release immune suppressive exosome-like nanovesicles bearing antigen/MHC complex
K. Nazimek, B. Nowak, M. Wasik, W. Ptak, P. W. Askenase, K. Bryniarski, Krakow, Poland   

 

 

WS.C4.02  Manipulation of Tolerance by FoxP3+T Regs
Monday, September 3, 2018; 10:15-11:30; Room: E102

IL-21 sustains asthmatic and colitogenic CD4+ T cell effector responses by promoting apoptosis of FoxP3+ regulatory T cells
L. Tortola, H. Pawelski, S. S. Sonar, M. Kopf, Zurich, Switzerland    

IL-10 signaling in CD11c+ myeloid cells prevents gluten-dependent intraepithelial CD4+ cytotoxic T lymphocyte infiltration and epithelial damage in the small intestine
L. M. M. Costes, D. J. Lindenbergh-Kortleve, L. A. van Berkel, S. Veenbergen, N. Papazian, Y. Simons-Oosterhuis, J. J. Karrich, R. M. Hoogenboezem, B. E. Clausen, T. Cupedo, J. N. Samsom, Rotterdam, Netherlands    

An autocrine TNFa - TNFR2 loop promotes epigenetic effects inducing human Treg stability in vitro
P. C. Urbano, H. J. Koenen, I. Joosten, X. He, Nijmegen, Netherlands    

Interleukin-34 contributes to Tregs suppressive function and inhibits allogeneics responses
A. Freuchet S. Bezie, C. Usal, V. Daguin, C. GuillOonneau, I. Anegon, Nantes, France    

Repairing Foxp3 mutations in scurfy T cells restores regulatory T cell function
l. Jeker, M. Kornete, Basel, Switzerland    

Epigenetic editing converts naive and memory CD4+ T cells into FOXP3 expressing regulatory T cells
C. Kressler, D. Hamo, G. Gasparoni, J. Walter, A. Hamann, J. K. Polansky, Berlin, Germany

WS.C5.01 Physiopathology of allergic disorders
Monday, September 3, 2018; 16:30-17:45; Room: E104-107

FcγRIIA/CD32A-expressing platelets determine the severity of experimental anaphylaxis
F. Jönsson, H. Beutier, B. Hechler, O. Godon, Y. Wang, C. M. Gillis, L. de Chaisemartin, A. Gouel-Chéron, S. Magnenat, L. Macdonald, A. Murphy, S. Chollet-Martin, D. Longrois, C. Gachet, P. Bruhns, NASA consortium, Paris, France    

Novel role for the acute phase protein serum amyloid A in the initiation of type 2 immunity
U. Smole, S. Lajoie, N. Gour, X. Xiao, J. Phelan, C. Köhler, N. Yao, L. Caraballo, E. Malle, S. Rosskopf, B. Kratzer, J. Chakir, A. Lane, W. Pickl, M. Wills-Karp, Vienna, Austria    

CD300c receptor co-stimulates IgE-mediated basophils activation and its expression is increased in cow´s milk allergic children
O. Zenarruzabeitia Belaustegi, J. Vitallé, I. Terrén, A. Orrantia, I. Astigarraga, L. Dopazo, C. González, C. Tutau, L. Santos-Díez, P. Gamboa, A. Bilbao, F. Borrego,, Barakaldo, Spain    

C5a receptor 1 activation on vacuolated eosinophils drives maladaptive immunity in experimental allergic asthma
A. V. Wiese, K. M. Quell, F. Ender, T. Vollbrandt, P. König, Y. Laumonnier, J. Köhl, Lübeck, Germany    

Single cell RNA-Seq identifies an exquisite pathogenic Th2 cell gene signature and pinpoints cellular metabolism as a major distinguishing factor
J. M. Coquet, Solna, Sweden    

Notch signaling in CD4+ T cells supports lymph node egress of Th2 cells in allergic airway inflammation
I. Tindemans, A. KleinJan, M. J. de Bruijn, M. Lukkes, A. van den Branden, W. F. van Ijcken, D. Amsen, R. Stadhouders, R. W. Hendriks, Rotterdam, Netherlands    

 

WS.C5.02  Immunotherapy of allergic disorders
Tuesday, September 4, 2018; 08:30-09:45; Room: G106-107

Selective elimination of allergen-specific B lymphocytes with chimeric protein-engineered molecules
N. R. Ralchev, N. Mihaylova, N. Kerekov, A. Tchorbanov,, Sofia, Bulgaria    

Sulfated Non-Anticoagulant Heparin (S-NACH) blocks allergen induced asthma manifestations in mice by modulating the IL-4/STAT6/GATA-3 pathway harboring a therapeutic potential for allergic asthma
M. A. Ghonim, J. Wang, S. Ibba, K. Pyakurel, H. Luu, I. Benslimane, S. Mousa, H. Boulares, New Orleans, LA, United States    

Targeting PDE3 Abrogates the Hallmarks of Asthma in Asthma Models
A. KleinJan, J. Beute, K. Ganesh, V. Bos, M. Lukkes, M. v. Nimwegen, S. Hockman, V. Manganiello, R. Hendriks, Rotterdam, The Netherlands

Neutrophils negatively regulate TH2 inflammation in allergic airways disease by limiting G-CSF driven monocytosis and ILC2 cytokine production
D. F. Patel, T. Peiro, J. Vuononvirta, S. Akthar, S. A. Walker, L. G. Gregory, C. M. Lloyd, R. J. Snelgrove, London, United Kingdom   

NOD/SCID-mice engrafted with human allergen-specific CD4+ T cells develop allergic airway responses without signs of GvHD
C. Vizzardelli, F. Zimmann, M. Gindl, B. Nagl, C. Kitzmüller, U. Vollmann, S. Tangermann, L. Kenner, B. Bohle, Vienna, Austria   

Induction of in vitro cross-tolerance in birch pollen-allergic patients with associated food allergies by use of tolerogenic dendritic cells
P. V. Rostan, E. Graulich, V. K. Raker, A. Wangorsch, S. Scheurer, K. Steinbrink, Mainz, Germany

WS.C6.01  Acquired immunity crosstalk with inflammation
Tuesday, September 4, 2018; 08:30-09:45; Room: E104-107

hIPSC-derived dendritic cells identify IRF5 as a crucial regulator that exacerbates inflammatory cytokine production during Influenza A virus infection
J. L. Forbester, M. Clement, A. Yeung, P. Sabberwal, M. Marsden, G. Dougan, I. Humphreys, Cardiff, United Kingdom    

SOCS1 and SOCS3 target IRF7 degradation to suppress TLR7- mediated type I interferon production of human plasmacytoid dendritic cells
C. Yu, W. Peng, M. Schlee, W. Barchet, A. M. Eis-Hübinger, W. Kolanus, M. Geyer, S. Schmitt, F. Steinhagen, J. Oldenburg, N. Novak, Bonn, Germany    

The dialogue between mast cells and B lymphocytes may precipitate atherosclerosis complications
A. Loste, K. Guedj, M. Clement, S. Delbosc, M. Morvan, G. Even, A. Gaston, M. Arock, A. Eggel, J. B. Michel, G. Caligiuri, A. Nicoletti, M. Le Borgne, Paris, France  

A role for DPP4 in T cell-mediated vascular inflammation and Atherosclerosis

J. Zhong, L. Duan, C. Xia, J. Varghese, G. Mihai, X. Rao, S. Rajagopalan, Cleveland, United States    

VISTA expression by microglia decreases during inflammation and is differentially regulated in CNS diseases
M. Borggrewe, C. Grit, W. F. den Dunnen, S. M. Burm, J. J. Bajramovic, R. J. Noelle, B. J. Eggen, J. D. Laman, Groningen, Netherlands    

CLEC12A regulates neutrophil functioning in Rheumatoid arthritis
L. Whitehead, P. Morvay, P. Redelinghuys, I. Dambuza, S. Ansboro, A. J. Roelofs, D. M. Reid, J. A. Willment, C. De Bari, I. B. McInnes, G. D. Brown, Aberdeen, United Kingdom    

 

WS.C6.02  New mediators in inflammation and its resolution
Tuesday, September 4, 2018; 16:30-17:45; Room: G104-105

PPAR-γ modulates macrophage response to lipopolysaccharide and glucocorticoids
M. Heming, S. Gran, S. Jauch, L. Fischer-Riepe, A. Russo, L. Klotz, S. Hermann, M. Schaefers, J. Roth, K. Barczyk-Kahlert, Muenster, Germany    

Anti-inflammatory microRNA-146a protects mice from diet-induced metabolic disease
M. C. Runtsch, M. Nelson, R. M. O'Connell, Salt Lake City, United States 

IFNb is a novel effector cytokine in resolving inflammation
A. Ariel, S. K. Satyanarayanan, S. Soboh, S. Butenko, J. Saadi, A. kassis, A. kassis, N. Peled, N. Sher, S. Schif-Zuck, Haifa, Israel    

CXCL9(74-103) reduces neutrophil recruitment and joint inflammation in experimental arthritis
D. Boff, H. Crijns, R. Janssens, V. Vanheule, G. B. Menezes, S. Macari, T. A. Silva, F. A. Amaral, P. Proost, Leuven, Belgium    

Inhibition of neutrophil extravasation with a CXCL9-derived glycosaminoglycan-binding peptide
P. Proost, V. Vanheule, A. Mortier, H. Crijns, D. Boff, R. Janssens, S. Struyf, F. A. Amaral, M. M. Teixeira, Leuven, Belgium    

Mechanisms by which lung surfactant protein SP-A amplifies IL-4-mediated effects on alveolar macrophages
C. Casals, B. García-Fojeda, C. Montero-Fernández, C. Stamme, C. M. Minutti, Madrid, Spain

 

WS.C6.03  Immune cells in tissue fibrosis
Wednesday, September 5, 2018; 12:00-13:15; E104-107

Plasmacytoid dendritic cells promote lung and skin fibrosis
R. R. Singh, S. Kafaja, A. Divekar, R. Saggar, F. Abtin, D. Khanna, D. Furst, I. Valera, Los Angeles, United States    

S100A8/A9 promotes parenchymal damage and renal fibrosis in obstructive nephropathy
A. Tammaro, Amsterdam, Netherlands    

CXCL4 drives inflammation and fibrosis on monocyte-derived dendritic cells through transcriptional and epigenetic imprinting
S. C. Silva-Cardoso, W. Tao, C. Angiolilli, A. Lopes, C. Bekker, J. van Laar, E. Hack, R. de Boer, M. Boes, A. Pandit, T. Radstake, Utrecht, Netherlands    

Liver sinusoidal endothelial cells trigger CD8 T cell mediated liver failure and herald liver regeneration
M. Luedemann, A. Gorol, L. A. D’Alessandro, S. Donakonda, U. Klingmueller, P. A. Knolle, Munich, Germany    

NLRP3- A key in the mediation of colitis into colitis-associated colorectal cancer
A. P. Perera, R. Eri, Launceston, Australia    

The IgE-FcεR1 axis strongly promotes epithelial hyperplasia and inflammation-driven skin carcinogenesis
M. Hayes, S. Ward, L. Wang, R. Castro Seoane, G. Crawford, J. Strid, London, United Kingdom

Workshops Track D

WS.D1.01  Mucosal immune regulation
Tuesday, September 4, 2018; 14:45-15:00; Room: G106-107

Transcription factor c-Maf is required for the control of Th17 cell responses by intestinal regulatory T cells
H. Hussein, S. Denanglaire, Y. Ajouaou, O. Leo, F. Andris, Gosselies, Belgium    

Induction of intestinal Th22 cells by segmented filamentous bacteria
U. Roy, E. Galvez, A. Gronow, M. Basic, A. Bleich, S. Huber, T. Strowig, Braunschweig, Germany    

Microbiota sensing by a Mincle-Syk axis in dendritic cells promotes intestinal immune barrier via the steady-state regulation of IL-17 and IL-22
M. Martínez-López, S. Iborra, A. Mastrangelo, R. Conde-Garrosa, C. Danne, D. M. Reid, G. D. Brown, D. Bernardo, S. Leibundgut-Landmann, D. Sancho, Madrid, Spain    

Control of RORγt+ regulatory T cell differentiation and intestinal immune homeostasis is dependent on the transcription factor c-Maf
C. Neumann, J. Blume, A. Vasanthakumar, A. Beller, U. Roy, Y. Liao, F. Heinrich, C. Stehle, G. A. Heinz, P. Maschmeyer, T. Sidwell, Y. Hu, D. Amsen, C. Romagnani, H. Chang, A. Kruglov, M. Mashreghi, W. Shi, T. Strowig, S. Rutz, A. Kallies, A. Scheffold, Berlin, Germany    

IL-17 receptor signaling in intestinal secretory progenitor cells regulates epithelial cells regeneration
P. Kumar, M. Beaupre, K. Chang, A. Banerjee, T. Chu, H. Huang, X. Lin, S. Khalid, P. Joshi, A. Bialowska, V. Yang, Stony Brook, United States    

Anti-commensal IgG augments intestinal inflammation in ulcerative colitis via IL-1 beta-dependent type 17 immunity
T. Castro-Dopico, T. W. Dennison, J. R. Ferdinand, R. Mathews, D. Clift, B. Stewart, C. Jing, K. Strongili, E. Monk, K. Saeb-Parsy, C. E. Bryant, M. Parkes, M. Clatworthy, Cambridge, United Kingdom    
 

 

WS.D1.02  Innate responses and immune signaling
Wednesday, September 5, 2018; 12:00-13:15; Room: G106-107

The microbiota protects against respiratory infection via GM-CSF signaling
T. B. Clarke, R. L. Brown, R. P. Sequeira, London, United Kingdom   

Hypercholesterolemia affects macrophage metabolism and function
J. Baardman, M. van Weeghel, S. Verberk, K. H. Prange, M. P. de Winther, J. Van den Bossche, Amsterdam, Netherlands   

MR1 recognition by human γδ T cells
J. Le Nours, N. Gherardin, S. Ramarathinam, W. Awad, B. Gully, R. Berry, F. Wiede, D. Fairlie, T. Tiganis, J. McCluskey, D. Pellicci, A. Uldrich, A. Purcell, D. Godfrey, J. Rossjohn,, Clayton, Australia   

RNA helicase DDX3 is a potent inducer of type I interferon and adaptive immunity
M. Stunnenberg, S. I. Gringhuis, T. B. Geijtenbeek, Amsterdam, Netherlands   

Recruitment of DC-SIGN+ monocyte-derived dendritic cells in the skin for antigen delivery and adaptive immunity
S. T. Schetters, L. J. Kruijssen, M. H. Crommentuijn, J. den Haan, Y. van Kooyk, Amsterdam, Netherlands   

Enhanced trained immunity by targeting SHIP-1 in myeloid cells
P. Saz-Leal, C. del Fresno, P. Brandi, S. Martínez-Cano, O. M. Dungan, J. D. Chisholm, W. G. Kerr, D. Sancho, Madrid, Spain   

 

WS.D1.03  Regulation of effector Immune responses
Wednesday, September 5, 2018; 13:45-15:00; Room: Forum

Intestinal dysbiosis driven by dietary trp deprivation limits myelin-reactive T cell responses in a murine multiple sclerosis model
J. K. Sonner, M. Keil, M. Falk-Paulsen, R. Bharti, N. Mishra, M. Kramer, K. Deumelandt, L. Wolf, I. Oezen, T. V. Lanz, I. Brandao, F. Wanke, Y. Tang, J. G. Okun, F. Kurschus, C. Reinhardt, W. Wick, P. Rosenstiel, M. Platten,, Heidelberg, Germany   

Gut dysbiosis induces dendritic-cell traffic from colon to pancreatic lymph node: implications for activation of islet-reactive T cells in type 1 diabetes
R. Toivonen, S. Silojärvi, S. Pöysti, E. Yatkin, A. Takeda, M. Miyasaka, A. Hänninen, Turku, Finland   

Imaging mass cytometry reveals the microanatomical location of B cell subsets in human gut associated lymphoid tissue
T. Tull, K. Todd, N. Petrov, R. Ellis, S. Heck, M. Bemark, J. Spencer, London, United Kingdom   

De novo fatty acid synthesis during mycobacterial infection is a prerequisite for the function of highly proliferative T cells, but not for dendritic cells or macrophages
L. Berod, P. Stueve, L. Minarrieta, C. Hölscher, T. Sparwasser, Hannover, Germany   

Cutting and pasting in the immunoproteome of infected cells
C. van Els, J. van Gaans-van den Brink, J. Liepe, H. Meiring, M. Mishto, A. Platteel, M. Poelen, A. Sijts, Utrecht, Netherlands   

Functional bias of effector memory CD8 T cells underlies the pathogenesis of Hepatitis E Virus in the elderly
J. Gouilly, F. Abravanel, E. Bahraoui, N. Jabrane-Ferrat, J. Izopet, H. El Costa,, Toulouse, France

WS.D2.01  Molecular properties of innate immune cells
Monday, September 3, 2018; 14:45-16:00; Room: E102

Non-apoptotic TRAIL function modulates NK cell activity during viral infection
L. Cardoso Alves, M. D. Berger, N. Kirschke, C. Lauer, N. Corazza, P. Krebs, Bern, Switzerland    

Recognition of host Clr-b by the inhibitory NKR-P1B receptor provides a basis for missing-self recognition
G. R. Balaji, O. A. Aguilar, Z. Fu, M. Tanaka, J. R. Carlyle, J. Rossjohn, R. Berry, Melbourne, Australia    

CD16A activation of NK cells primes memory-like cytotoxicity against cancer cells
J. Pahl, J. Koch, J. Götz, A. Arnold, U. Reusch, T. Gantke, E. Rajkovic, M. Treder, A. Cerwenka,, Mannheim, Germany    

Dynamic changes in intrathymic ILC populations during neonatal development
R. Jones, G. Anderson, D. R. Withers, Birmingham, United Kingdom    

Innate lymphoid cell reconstitution post lethal irradiation and bone marrow transplant
R. Albugami, R. Alhamawi, C. Dempsey, C. Willis, D. Withers, N. Jones, Birmingham, United Kingdom    

Killer cell Immunoglobulin-like receptor 3DL1 polymorphism defines distinct hierarchies of antigen recognition
J. P. Vivian, P. Saunders, P. Pymm, J. Rossjohn, A. Brooks, Clayton, Australia    

 

WS.D2.02  Molecular and cellular features of ILCs
Tuesday, September 4, 2018; 16:30-17:45; Room: E102

Hobit specifically identifies ILC1 throughout peripheral tissues
R. L. R. Taggenbrock, N. A. Kragten, F. M. Behr, L. Parga Vidal, T. H. Wesselink, R. Stark, G. Gasteiger, K. P. van Gisbergen, Amsterdam, Netherlands    

Human IL-17-producing type 2 innate lymphoid cells are important regulators of neutrophilia in cystic fibrosis
K. Golebski, X. R. Ros, M. Nagasawa, B. A. Heesters, C. M. van Drunen, W. J. Fokkens, H. Spits, S. M. Bal, Amsterdam, Netherlands    

ILC migration between barriers sites and draining lymphoid tissue
E. Dutton, C. Willis, A. Camelo, M. Sleeman, G. Carlesso, R. Herbst, A. Humbles, D. Withers, Birmingham, United Kingdom    

The chemokine receptor CCR8 regulates effector functions of group 2 innate lymphoid cells
L. Knipfer, A. Schulz-Kuhnt, M. Kindermann, T. Primbs, D. Vöhringer, M. Neurath, I. Atreya, S. Wirtz, Erlangen, Germany    

Molecular definition of group 1 innate lymphoid cells in the mouse uterus
I. Filipovic, L. Chiossone, P. Vacca, R. S. Hamilton, J. Doisne, A. Sharkey, C. Mingari, L. Moretta, F. Colucci,, Cambridge, United Kingdom    

NCR+ ILC3 maintain larger STAT4 reservoir via T-BET to regulate type 1 features upon IL-23 stimulation in mice
Y. Mikami, G. Scarno, B. Zitti, H. Shih, Y. Kanno, A. Santoni, J. J. O'Shea, G. Sciume, Rome, Italy

WS.D3.01 Novel vaccine approches to intracellular pathogens
Monday, September 3, 2018; 14:45-16:00; Room: G106-107

Targeted delivery of BCG vaccine to the DEC-205 receptor improves protective efficacy against Mycobacterium tuberculosis
C. Counoupas, R. Pinto, L. Baker, G. Ngalingam, A. Nisa, W. Britton, J. Triccas, Sydney, Australia    

HLA-E restricted human CD8+ T-cells: a novel human T-cell subset with unique properties which impact vaccination strategies against tuberculosis
S. A. Joosten, K. E. van Meijgaarden, T. Prezzemolo, A. M. Drittij, K. L. Franken, C. K. Dingenouts, P. Ruibal, T. H. Ottenhoff, Leiden, Netherlands    

During experimental tuberculosis, interleukin-27R regulates protection and limits the expansion of multifunctional T cells by inhibiting interleukin-17A
K. Ritter, J. Behrends, A. Hölscher, J. Volz, I. Rosenkrands, H. Erdmann, C. Hölscher, Borstel, Germany    

Human Plasmodium falciparum infection induces a predictable and persistent distortion in transcriptomic landscapes across T cell subsets
T. S. Watkins, F. Amante, S. Turner, S. Darko, A. Ransier, D. L. Doolan, D. C. Douek, J. S. McCarthy, J. J. Miles, Cairns, Australia    

BCG-induced trained innate immunity during controlled human malaria infection
J. Walk, C. de Bree, W. Graumans, R. Siebelink-Stoter, G. van Gemert, M. van de Vegte-Bolmer, K. Teelen, C. C. Hermsen, R. J. Arts, M. C. Behet, S. J. Moorlag, A. Yang, R. van Crevel, P. Aaby, Q. de Mast, A. J. van der Ven, C. Stabell Benn, M. Netea, R. W, Nijmegen, Netherlands    

Evaluation of multi-epitope peptides derived from different Leishmania proteins as potential vaccine candidates against human Leishmaniasis
S. Hamrouni, K. Aoun, A. Kidar, R. Chamakh Ayari, E. Petitdidier, J. Lemesre, R. Bras Gonçalves, A. Meddeb Garnaoui, Tunis, Belvédère, Tunisia

 

WS.D3.02 Novel vaccine approaches for viruses
Wednesday, September 5, 2018; 08:30-09:45; Room: G102-103

Deciphering the complexity of vaccine-induced immunity with omics technologies: innate immune responses differ between priming and boosting immunization
J. L. Palgen, N. Tchitchek, J. Elhmouzi-Younes, S. Delandre, I. Namet, N. Huot, P. Rosenbaum, N. Dereuddre-Bosquet, F. Martinon, A. Cosma, M. Müller-Trutwin, Y. Lévy, R. Le Grand, A. S. Beignon, Fontenay-aux-Roses, France    

Identification of vaccine responding T-cells using TCR repertoire sequencing data
M. V. Pogorelyy, A. A. Minervina, M. Puelma Touzel, E. A. Komech, E. I. Kovalenko, G. G. Karganova, E. S. Egorov, A. Y. Komkov, D. M. Chudakov, I. Z. Mamedov, T. Mora, A. M. Walczak, Y. B. Lebedev, Moscow, Russian Federation    

Mucosal vaccine mediates cross-protection by immune training
P. Brandi, L. Conejero, F. Cueto, S. Martinez-Cano, P. Saz-Leal, M. Enamorado, J. Amores-Iniesta, J. Subiza, D. Sancho, Madrid, Spain    

Liver-resident memory CD8 T cells develop during chronic viral infection, have reduced effector functions but can be reactivated to clear persistent viral infection of hepatocytes
M. Bosch, K. Manske, S. Donakonda, D. Wohlleber, P. A. Knolle, N. Kallin, Munich, Germany    

Harnessing T-helper (Th) cell responses induced by licensed vaccines for HIV vaccine development
H. Elsayed, G. Nabi, W. J. Mckinstry, M. Tenbusch, V. Temchura, K. Überla, Erlangen, Germany    

Design of TLR2 ligand-synthetic long peptide conjugates for therapeutic vaccination of chronic HBV patients
Y. Dou, D. T. S. Jansen, A. van den Bosch, R. A. de Man, N. van Montfoort, G. G. Zom, W. Krebber, C. J. Melief, A. M. Woltman, S. I. Buschow, Rotterdam, Netherlands

WS.D4.01 Protective mechanisms for microbial pathogens
Sunday, September 2, 2018; 16:30-17:45; Room: E104-107

Different composition and functional properties of splenic T cells in experimental cerebral malaria-susceptible C57BL/6 wildtype and protected Ifnar1-/- mice
J. J. Reichwald, P. J. Korir, L. Jenster, A. Mueller, A. Hoerauf, B. Schumak, Bonn, Germany    

A distinct subset of human CD56+ cells present at baseline in HbAS-SCT-children is associated with a lower parasite density during an episode of clinical malaria
C. Loiseau, O. K. Doumbo, B. Traore, J. L. Brady, C. Proietti, P. D. Crompton, D. L. Doolan,, Cairns, Australia    

Transcription factor T-bet plays a complex role in B cell mediated immune response against Plasmodium infection
M. Akkaya, P. W. Sheehan, C. K. Cimperman, B. P. Theall, M. Pena, S. K. Pierce, Rockville, United States    

Within host-adaptation of Bordetella pertussis under vaccine immune pressure
E. van Schuppen, A. Zeddeman, K. E. Kok, M. van Gent, K. J. Heuvelman, M. J. Bart, H. G. van der Heide, F. J. van Opzeeland, S. van Selm, M. I. de Jonge, R. de Groot, F. R. Mooi, D. A. Diavatopoulos, Nijmegen, Netherlands    

Transphagocytosis, a novel mechanism for bacterial uptake by B cells
R. García Ferreras, G. Ramírez Santiago, A. Cruz Adalia, J. Osuna Pérez, M. Torres Torresano, Y. R. Carrasco, E. Veiga Chacón, Madrid, Spain    

Human vaginal and skin dendritic cell subsets control ZIKA virus infection
J. Eder, T. B. Geijtenbeek, Amsterdam, Netherlands

 

WS.D4.02 Responses to mucosal microbial pathogens
Monday, September 3, 2018; 08:30-09:45; Room: G104-105

Combined chemical genetics and data-driven bioinformatics approach identifies receptor tyrosine kinase inhibitors as host-directed drugs for intracellular bacterial infections
C. J. Korbee, M. T. Heemskerk, D. Kocev, E. van Strijen, O. Rabiee, K. L. Franken, L. Wilson, N. D. Savage, S. Džeroski, T. H. Ottenhoff, M. C. Haks, Leiden, Netherlands    

Host-directed, autophagy-modulating compounds restrict intracellular Mycobacterium tuberculosis and Salmonella Typhimurium infection in human macrophages
M. T. Heemskerk, C. J. Korbee, J. Esselink, C. Carvalho dos Santos, F. Vrieling, I. Gordijn, L. Wilson, T. H. Ottenhoff, M. C. Haks, Leiden, Netherlands    

The Mal-IFN-γ receptor axis receptor axis and TIRAP-S180L polymorphism as determinants of susceptibility to pneumococcal disease.
N. Munoz-Wolf, C. M. Ni Cheallaigh, M. Herrlein, D. Golenbock, K. A. Fitzgerald, L. A. O'Neill, E. C. Lavelle, Dublin, Ireland    

Dual RNA-seq unveils novel host-pathogen interactions during colonic bacterial infections
F. Wan, Baltimore, United States    

iNOS- AND NOX1- DEPENDENT ROS PRODUCTION MAINTAINS BACTERIAL HOMEOSTASIS IN THE ILEUM OF MICE
A. Kielland, C. Matziouridou, S. Rocha, K. Rudi, O. A. Haabeth, H. Carlsen, Ås, Norway    

NLRP11 negatively regulates NF-κB and type I interferon responses
K. Ellwanger, E. Becker, I. Kienes, A. Sowa, Y. Postma, Y. Cardona Gloria, A. N. Weber, T. A. Kufer, Stuttgart, Germany

 

WS.D4.03  Immune sensing of microbial infections
Monday, September 3, 2018; 16:30-17:45; Room: G106-107

Functional cooperation between complement factor H and the long pentraxin PTX3 in the immune response to Aspergillus fumigatus
R. Parente, F. Petroni, M. Stravalaci, M. Sironi, R. Leone, S. Valentino, A. J. Day, B. Bottazzi, A. Mantovani, A. Inforzato, Rozzano, Italy    

Orchestration of systemic anti-fungal Th17 immunity and immune pathology by a single member of the mycobiome
P. Bacher, T. Hohnstein, E. Beerbaum, M. Röcker, S. Kaufmann, C. Brandt, J. Röhmel, U. Stervbo, M. Nienen, N. Babel, J. Milleck, M. Assenmacher, O. A. Cornely, G. Heine, M. Worm, P. Creutz, C. Ruwwe-Glösenkamp, L. E. Sander, O. Kniemeyer, A. A. Brakhage, Berlin, Germany    

Human blood monocytes from anti-inflammatory vesicles in response to pathogenic Candida albicans
L. D. Halder, E. A. Jo, M. F. Gomes, S. Babych, T. Krüger, O. Kniemeyer, B. Jungnickel, P. F. Zipfel, C. Skerka, Jena, Germany    

Inherited p40phox deficiency differs from chronic granulomatous disease: Distinctive molecular, cellular and clinical phenotypes
A. van de Geer, A. Nieto-Patlán, D. Roos, J. Casanova, T. W. Kuijpers, J. Bustamante, Amsterdam, Netherlands    

TRIM5α-mediated autophagy: Where HIV-1 restriction and molecular inflammation meet
A. P. Cloherty, J. L. van Hamme, R. Sarrami-Forooshani, N. A. Kootstra, T. B. Geijtenbeek, C. M. S. Ribeiro, Amsterdam, Netherlands    

Type I interferon-dependent NETosis supports biofilm formation and survival of Pseudomonas aeruginosa during lung infection
E. Pylaeva, S. Bordbari, I. Spyra, S. Lang, J. Jablonska, Essen, Germany

 

WS.D4.04  Virus-host interactions
Tuesday, September 4, 2018; 08:30-09:45; Room: Forum

Human cytomegalovirus reprograms hematopoietic progenitor cells into immunosuppressive monocytes to achieve latency
K. Zen, Atlanta, China    

Killer cell proteases target viral immediate-early proteins to control cytomegalovirus infection in a noncytotoxic manner
L. Shan, J. Meeldijk, B. Blijenberg, A. Hendriks, K. J. van Boxtel, S. P. van den Berg, A. Svrlanska, T. Stamminger, M. R. Wills, N. Bovenschen, Utrecht, Netherlands    

Pathological role of anti-CD4 antibodies in HIV-infected immunologic non-responders under viral suppressive antiretroviral therapy
W. Jiang, Z. Luo, Charleston, United States    

HIV-1 exposure enhances sexual transmission of HCV by inducing Syndecan-4 on Langerhans cells
B. M. Nijmeijer, R. Sarrami Forooshani, J. Eder, G. S. Steba, R. R. Schreurs, S. M. Koekkoek, R. Molenkamp, J. Schinkel, P. Reiss, M. L. Siegenbeek van Heukelom, M. van der Valk, C. M. Ribeiro, T. B. Geijtenbeek, Amsterdam, Netherlands    

DUSP4 regulates STING and RIG-I mediated signalling in response to virus infection
H. Jiao, S. J. James, Y. Zhang, Singapore, Singapore    

A lncRNA promotes viral replication by modulating host cellular metabolism
P. Wang, J. Xu, Y. Wang, X. Cao, Shanghai, China    

 

WS.D4.05  Innate-adaptive interface during microbial infections
Tuesday, September 4, 2018; 10:15-11:30;
Room: G106-107

Targeting newly identified pathogenic monocyte subsets with immune-modulatory treatment resolves severe malaria
P. Niewold, A. Cohen, C. van Vreden, D. R. Getts, G. Grau, N. King, Sydney, Australia    

The use of mass cytometry to study type 2 immune responses in the context of helminth infections
K. de Ruiter, D. L. Tahapary, K. Stam, V. van Unen, E. Sartono, J. W. Smit, T. Supali, M. Yazdankbakhsh, Leiden, Netherlands    

The Notch signaling pathway controls basophil responses during helminth-induced type 2 inflammation
L. M. Webb, S. A. Peng, O. O. Oyesola, R. L. Cubitt, J. K. Grenier, C. G. Danko, E. D. Tait Wojno, Ithaca, United States    

Type I Interferons Suppresses Anti-parasitic CD4+T Cell Responses in Visceral Leishmaniasis
R. Kumar, P. Bunn, F. Rivera, N. Singh, S. Sundar, C. Engwerda, Varanasi, India    

Cross-presentation by pDC of cell-associated HIV is potentiated by non-cognate CD8 T+ cell pre-activation
E. X. Hatton, S. Isnard, M. Iannetta, J. Guillerme, A. Hosmalin, Paris, France    

Memory CD8 T cell inflation versus tissue resident memory T cells: same patrollers, same controllers?
S. P. M. Welten, A. Oxenius, Zürich, Switzerland    

 

WS.D4.06 Bacterial infections and immune activation
Tuesday, September 4, 2018; 16:30-17:45;
Room: G102-103

A novel mechanism of neutrophil entry into epithelial cells is involved in damping inflammation but exposes a backdoor for bacterial invasion
N. Y. Shpigel, Rehovot, Israel    

Lung surfactant lipids provide immune protection against non-typeable Haemophilus influenzae respiratory infection
B. Garcia-Fojeda, Z. Gonzalez-Carnicero, A. De Lorenzo, C. Minutti, B. Euba, A. Iglesias-Ceacero, S. Castillo-Lluva, J. Garmendia, C. Casals, Madrid, Spain    

CD200R1L, a novel activating receptor on human neutrophils that induces ROS and NET release
M. Ramos, J. Stok, C. Kesmir, T. Jansen, L. Meyaard, M. van der Vlist, Utrecht, Netherlands    

Innate immune recognition of Staphylococcus aureus by dendritic cells is affected by antibiotic resistance mutations
T. P. Patton, J. Jiang, R. J. Lundie, V. Oorschot, G. Ramm, A. Y. Peleg, M. A. O'Keeffe, Melbourne, Australia    

Hemolysin liberates bacterial outer membrane vesicles for cytosolic lipopolysaccharide sensing
S. Chen, Q. Liu,, ShangHai, China    

Analysis of CD6-based peptides in experimental sepsis
C. Català, M. Martínez-Florensa, M. Velasco-de Andrés, O. Cañadas, V. Fraile-Ágreda, S. Casadó-Llombart, N. Armiger-Borràs, M. Consuegra-Fernández, C. Casals, F. Lozano, Barcelona, Spain

 

 

WS.D4.07 Innate immune responses and infection
Wednesday September 5, 2018; 08:30-09:45;
Room: E102

Primary neutrophil defects reveal the mechanisms of neutrophil extracellular trap (NET) formation and NETosis: a unique role for active cytoskeletal rearrangments 
E. Sprenkeler, A. Tool, T. K. van den Berg, T. Kuijpers, Amsterdam, The Netherlands

Characterization of neutrophils generated in vitro from Hoxb8-transduced myeloid progenitor cells
A. Orosz, A. Mócsai, Budapest, Hungary

Regnase-3 is an essential RNase for the Interferon pathway in tissue macrophages 
M. Von Gamm, A. Schaub, J. Lichti, M. Tschöp, V. Hornung, C. Schulz, M. Heikenwälder, E. Glasmacher, Munich, Germany

A viral immunoevasin controls innate immunity by targeting the prototypical natural killer cell receptor family 
O. Aguliar, R. Berry, M. Rahim, J. Reichel, B. Popovic, M. Tanaka, Z. Fu, G. Balaji, T. Lau, M. Tu, C. Kirkham, A. Mahmoud, A. Mesci, A. Krmpotic, D. Allan, A. Makrigiannis, S. Jonjic, J. Rossjohn, J. Carlyle, Clayton, Australia

Intracellular lifestyle of the probiotic bacteria Lactobacillus plantarum; implications for its extraintestinal dissemination 
A. Pellon, E. Atondo, M. Montesinos-Polledo, M. A. Pascual-Itoiz, A. Peña-Cearra, A. Carreras-Gonzalez, S. Varona-Fernandez, J. M. Landete, J. M. Rodriguez, R. Prados-Rosales, L. Abecia, J. L. Lavin, J. Anguita, H. Rodriguez, Derio, Spain

Nanovaccines to prevent listeriosis in the elderly
C. Alvarez-Dominguez, R. Calderon-Gonzalez, H. Teran-Navarro, D. Salcines-Cuevas, M. Fresno-Escudero, Santander, Spain

Workshops Track E

WS.E1.01 Visualizing immune responses
Tuesday, September 4, 2018; 08:30-09:45;
Room: E102

A hot trick for efficient peptide exchange on MHC class I multimers
J. J. Luimstra, M. A. Garstka, M. C. Roex, F. H. Falkenburg, J. Neefjes, H. Ovaa, Leiden, Netherlands    

Chemokines and integrins independently tune actin flow and substrate friction during intranodal migration of T cells
M. Hons, A. Kopf, R. Hauschild, A. Leithner, F. Gärtner, J. Abe, J. Renkawitz, J. V. Stein, M. Sixt, Klosterneuburg, Austria    

Inside the infected lung - Watching immune cells battle Aspergillus fumigatus
S. Henneberg, S. Krappmann, L. Bornemann, M. Hasenberg, J. Weski, A. Hasenberg, M. Gunzer, Essen, Germany    

Imaging of cytotoxic antiviral immunity while considering the 3R principle of animal research
L. Otto, G. Zelinskyy, M. Schuster, U. Dittmer, M. Gunzer, Essen, Germany    

Visualisation of immune receptor sequences via projection into high-dimensional space with Siamese neural networks
V. I. Nazarov, E. Ofitserov, V. Tsvetkov,, Moscow, Russian Federation

Intravascular resident Natural Killer cells shape neutrophil dynamics in the pulmonary vasculature
J. Secklehner, K. De Filippo, J. B. Mackey, J. Vuononvirta, X. Raffo Iraolagoitia, A. McFarlane, M. Neilson, M. B. Headley, M. Krummel, N. Guerra, L. M. Carlin, London, United Kingdom

WS.E2E3.01 Single cells to population dynamics and handling Big Data
Monday, September 3, 2018; 10:15-11:30;
Room: G104-105

MHC class II-omics for full understanding of MHC class II antigen presentation
M. L. Jongsma, R. Wijdeven, B. Cabukusta, D. Borras, P. Paul, T. van den Hoorn, J. Neefjes, Leiden, Netherlands    

High affinity T cell receptor generate both active and memory cytotoxic response during a viral infection
F. Luciani, S. Rizzetto, A. Eltahla, C. Cai, E. Keoshkerian, K. Wing, D. Koppstein, W. Van der Byl, K. Shober, M. Effemberger, R. Bull, A. R. Lloyd, D. Busch, Sydney, Australia    

A Semi-Unsupervised Multivariate Algorithm for Mining and profiling High-dimensional Flow Cytometry Data
P. C. Martins Urbano, L. Rosaria, W. Alkema, A. Koerber, E. de Jong, F. Hoentjen, I. Joosten, H. J. Koenen, Nijmegen, Netherlands    

Single cell transcriptomes define the cellular and molecular landscape of human lungs in asthma
F. Vieira Braga, G. Kar, T. Gomes, E. S. Fasouli, P. Strzelecka, K. Polanski, M. Efremova, K. Mahbubani, A. Cvejic, K. Saeb-Parsy, O. A. Carpaij, M. Berg, S. Brouwer, K. Affleck, M. van den Berge, A. van-Oosterhout, M. Nawijn, S. A. Teichmann, Cambridge, United Kingdom    

DiSNE visualization and assessment of clonal kinetics reveals multiple trajectories of dendritic cell development
D. Lin, A. Kan, J. Gao, E. Crampin, P. Hodgkin, S. Naik, Melbourne, Australia    

CD4 T cell transcriptomics reveals novel diagnostic and mechanistic immune signatures of tuberculosis
J. G. Burel, C. S. Lindestam Arlehamn, M. Pomaznoy, N. Khaan, G. Seumois, J. A. Greenbaum, D. DeSilva, R. Taplitz, R. H. Gilman, M. Saito, P. Vijayanand, A. Sette, B. Peters, La Jolla, United States

WS.E4.01 Cell communication and signaling in the immune system
Monday, September 3, 2018; 16:30-17:45;
Room: G104-105

Mechanotransduction as a novel immune checkpoint in NK cell cytotoxicity
M. Barda-Saad, A. Ben-Shmuel, O. Matalon, J. Kivelevitz, B. Sabag, N. Joseph, G. Biber, Ramat-Gan, Israel    

Combining FACS, High-Resolution Mass-spectrometry, and Single Cell Sequencing Reveals Interactome Effects of Translational Control
M. D. Stadnisky, R. Halpert, S. Siddiq, J. Spidlen, J. Almarode, M. Velazquez-Palafox, I. Taylor, C. Freier, Ashland, United States    

Helper T cell extracellular vesicles couple delivery of effector CD40L to antigen recognition
E. B. Compeer, D. G. Saliba, P. F. Céspedes, Š. Bálint, K. Korobchevskaya, C. Cassioli, M. L. Dustin, Oxford, United Kingdom    

Itaconate is an anti-inflammatory metabolite that activates Nrf2 via alkylation of KEAP1
D. G. Ryan, Dublin, Ireland    

Sugar sweet signalling; Exploration of dendritic cell lectin receptors and their immune modulatory signalling pathways
R. J. E. Li, J. E. Rodriguez-Camejo, J. Lübbers, A. Zaal, C. R. Jimenez, S. R. Piersma, T. V. Pham, R. R. de Goeij- de Haas, S. J. van Vliet, Y. van Kooyk, Amsterdam, Netherlands    

DLL4 conveys Notch-dependent signals achieving selective macrophage polarization or death
B. Charreau, S. Pagie, A. Pabois, N. Gérard, C. Toquet, P. Hulin, S. Nedellec, Nantes, France